Words similar to micronized
Example sentences for: micronized
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To overcome this problem, CAP in a micronized form was used and proven to have virucidal activity against HIV-1 IIIB [ 31 ] and shown to be effective in reducing vaginal infection by simian immunodeficiency virus (SIV) in a macaque model [ 34 ] . Micronized CAP provides a low pH buffering system and this may have contributed to its virucidal properties.
Since CAP, unlike the other polymers listed above, is not soluble at low pH, characteristic for a normal vaginal environment [ 42 ] , micronized forms of CAP had to be used in microbicidal formulations of this compound [ 30 31 32 33 34 ] . Therefore, it was of interest to determine how CAP in micronized form and other candidate polymeric microbicides affect X4 and R5 viruses represented by HIV-1 IIIB and BaL, respectively.
In order to correlate the properties of CAP in soluble and micronized forms, it was necessary to establish whether or not micronized CAP would bind HIV-1 virus particles and HIV-1 envelope glycoproteins, and induce the formation of gp41 six-helix bundles, a marker of irreversible virus inactivation, as did soluble CAP [ 37 ] . First it was established that HIV-1 gp120 bound to micronized CAP (provided in the form of micronized CAP particles or of a commercial product, "Aquateric", containing about 66% of CAP and used for enteric coating of tablets and capsules in the pharmaceutical industry [ 54 ] ); (Fig.
2)), this would be expected to physically remove virus particles by adsorption onto micronized CAP (Aquateric) so that they would cease to be available to initiate the complex sequence of events leading to mucosal infection.
Elicitation of gp41 six-helix bundles and virucidal activity represent shared properties between micronized and soluble (at sufficient concentrations) forms of CAP [ 37 ] .
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