Words similar to micronized
Example sentences for: micronized
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Recombinant gp120 HIV-1 IIIB in the presence of a 10-fold excess of BSA and gelatin, respectively, was quantitated by adding the gp120/BSA/gelatin mixtures (before and after binding to micronized CAP or Aquateric; Fig.
To overcome this problem, CAP in a micronized form was used and proven to have virucidal activity against HIV-1 IIIB [ 31 ] and shown to be effective in reducing vaginal infection by simian immunodeficiency virus (SIV) in a macaque model [ 34 ] . Micronized CAP provides a low pH buffering system and this may have contributed to its virucidal properties.
To avoid this, CAP in micronized form (which does not aggregate at low pH), instead of CAP in soluble form is being considered as a topical microbicide [ 30 31 32 33 34 35 ] . Micronized CAP (Aquateric) was shown to be virucidal against HIV-1, herpesviruses and several nonviral sexually transmitted disease (STD) pathogens [ 30 31 32 33 34 ] . The virucidal activity of micronized CAP could at least partly be explained by its buffering capacity at low pH [ 40 ] since it is a free acid while other anionic polymeric microbicide candidates (except BufferGel, the active ingredient of which is Carbomer 974P [ 27 ] ) are sodium salts.
Results shown above indicated that HIV-1 adsorbed onto micronized CAP and that the CAP - virus interaction lead to the formation of gp41 six-helix bundles, a hallmark for HIV-1 inactivation.
2) in the presence of an excess of nonviral proteins, including seminal fluid, bind effectively to micronized CAP.
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