Words similar to micrometastases
Example sentences for: micrometastases
How can you use “micrometastases” in a sentence? Here are some example sentences to help you improve your vocabulary:
The aim of this study was to evaluate the accuracy of detecting and interpreting micrometastases in the sentinel lymph nodes of patients with cutaneous melanoma utilizing this cocktail in a single section instead of three adjacent sections needing each of the three immunomarkers in the cocktail.
During interpretation of sentinel lymph nodes, the diagnosis of melanoma is known and the aim is to detect the melanoma micrometastases of the known primary.
Previously, we had demonstrated higher diagnostic accuracy in detecting and diagnosing melanoma micrometastases in sentinel lymph node using monoclonal antibodies to MART-1 (clone M2-7C10) and Melan-A (clone A103) in comparison to the traditionally used immunohistochemical markers, S-100 protein (S-100) and HMB-45 [ 6 ] . The cytoplasmic staining with these immunomarkers does not obscure the nuclear details and facilitates accurate interpretation of tumor cells, macrophages, and nevus cells in contrast to S-100 [ 6 12 ] . A monoclonal antibody to a third melanoma immunomarker, Tyrosinase (clone T311), showed an immunostaining pattern similar to MART-1 and Melan-A [ 13 ] .
Thus, MART-1 and Melan-A individually could not detect micrometastases in 16% (4/25) of the slices.
Thus, a highly sensitive immunomarker such as S-100 is less effective for interpretation of sentinel lymph nodes for melanoma micrometastases (especially when present as single cells) than MART-1 and Melan-A [ 6 ] . Certain morphological features help to differentiate melanoma cells and other non-melanoma cells such as S100 immunoreactive dendritic cells in sentinel lymph nodes.
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