Words similar to micrometastases

Example sentences for: micrometastases

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Of the 188 sections immunostained with 'melanoma cocktail', 41 sections (8/24 cases) were positive for melanoma micrometastases (Figure 2A& 2B).
These four slices (from 2 lymph nodes of 2 cases), negative for micrometastases with MART-1 and Melan-A, showed melanoma micrometastases predominantly as single cells.
Thus, a highly sensitive immunomarker such as S-100 is less effective for interpretation of sentinel lymph nodes for melanoma micrometastases (especially when present as single cells) than MART-1 and Melan-A [ 6 ] . Certain morphological features help to differentiate melanoma cells and other non-melanoma cells such as S100 immunoreactive dendritic cells in sentinel lymph nodes.
At present histomorphologic examination with immunohistochemistry remains the most reliable and practical means of detecting melanoma micrometastases in sentinel lymph nodes [ 6 21 ] . MART-1 and Melan-A are two antibodies to different epitopes of the same antigen and are complementary to each other.
However, as demonstrated in our previous study, it is not uncommon to face an equivocal situation when S-100 protein is used as an immunomarker for the interpretation of single melanoma micrometastases in sentinel lymph nodes [ 6 ] . Based on our previous study with HMB45 [ 6 ] and an initial study with micropthalmia transcription factor [ 22 ] , these immunomarkers were not considered suitable for inclusion in the cocktail due to the immunoreactivity of non-melanoma cells in the sentinel lymph nodes.