Words similar to microgyria
Example sentences for: microgyria
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Here we present evidence that induced bilateral focal microgyria leads to significant reductions in overall brain weight that are quite robust, being seen at all ages measured (P30 - P118), in both males and females, and are unaffected by acoustic rearing experiences.
Analysis of histologic brain and neocortical volume confirmed the effects of lesion on brain weight, and suggest that the reduction in volume associated with microgyria is proportionally greater in the cerebral cortex.
Further, animals with induced microgyria showed poorer performance in discrimination learning and took longer paths to the target in the Morris Water Maze than sham littermates [ 22 ] .
For example, the presence of neocortical malformations in certain strains of inbred mice are correlated with better performance on tasks of spatial reference memory [ 17 18 ] . On the other hand, induced microgyric animals show a variety of behavioral deficits that suggest disturbances to multiple brain systems [ 15 19 20 21 22 ] . Rapid auditory processing deficits have been found in males with induced microgyria using both an operant condition paradigm and a reflex modification paradigm [ 15 19 20 21 ] . In both paradigms, auditory processing deficits were found only on rapidly changing stimuli, and not when these same stimuli were delivered at slower rates.
It has been shown that these malformations, resembling human microgyria, are associated with widespread disturbances in neuronal organization [ 4 5 ] . For example, brain slices containing microgyric cortex show increased epileptogenic activity [ 6 7 8 9 ] . Microgyric anomalies are also associated with connectional alterations [ 10 11 12 ] , affecting both thalamic and cortico-cortical connectivity.
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