Words similar to metabotropic
Example sentences for: metabotropic
How can you use “metabotropic” in a sentence? Here are some example sentences to help you improve your vocabulary:
In hippocampal slice preparations, γ oscillations can be triggered by high frequency tetanic stimuli, called post-tetanic γ oscillations [ 10 11 12 13 ] . In addition to post-tetanic γ oscillations, the γ oscillations also can be elicited by metabotropic glutamate receptor agonists, carbacol, or free extracellular Mg 2+ [ 18 19 ] . In this study, we report that γ oscillations can occur in a model of a clinical disorder, namely hyperthermia.
Metabotropic glutamate receptors (mGluRs) are a family of class 3 G protein-coupled receptors with important functions in the regulation of synaptic transmission, plasticity, neuronal excitability, and the regulation sensory transduction [ 1 2 3 4 5 ] . The eight mGluRs (mGluR1-8) and their splice variants have been divided into three groups (I-III) based on sequence homology, pharmacology and G protein coupling profiles [ 3 6 7 ] . Group II (mGluR2 and 3) and III (mGluR4, and 6 through 8) couple negatively to adenylate cyclase through activation of the G i/o family of G proteins [ 8 ] . Group I mGluRs (mGluR1 and 5) couple to multiple G proteins in native and heterologous systems, and have been observed to couple to G q/11 , G i/o and/or G s [ 9 10 11 12 13 14 15 ] . mGluRs appear to be important mediators of synaptic transmission in the brain.
The findings described here demonstrate that the mammalian homologue of seven in absentia, Siah1a regulates the function of group I metabotropic glutamate receptors.
This polyproline tract is immediately adjacent to a disordered surface loop found in MoeB proteins thought to be involved in protein-protein interactions [ 7 ] . The consensus for this motif (RXLYPEPPPP) closely corresponds to a sequence (RSLYPPPPPP) found in rat and human metabotropic 1 glutamate receptors [ 28 29 ] . This motif is reminiscent of protein-protein interaction domains found in some proteins [ 30 ] ; however, interactions of this type have not been shown to be facilitated by the polyproline motif in rat and human metabotropic 1 glutamate receptors.
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