Words similar to metabotropic
Example sentences for: metabotropic
How can you use “metabotropic” in a sentence? Here are some example sentences to help you improve your vocabulary:
This polyproline tract is immediately adjacent to a disordered surface loop found in MoeB proteins thought to be involved in protein-protein interactions [ 7 ] . The consensus for this motif (RXLYPEPPPP) closely corresponds to a sequence (RSLYPPPPPP) found in rat and human metabotropic 1 glutamate receptors [ 28 29 ] . This motif is reminiscent of protein-protein interaction domains found in some proteins [ 30 ] ; however, interactions of this type have not been shown to be facilitated by the polyproline motif in rat and human metabotropic 1 glutamate receptors.
Metabotropic glutamate receptors (mGluRs) are a family of class 3 G protein-coupled receptors with important functions in the regulation of synaptic transmission, plasticity, neuronal excitability, and the regulation sensory transduction [ 1 2 3 4 5 ] . The eight mGluRs (mGluR1-8) and their splice variants have been divided into three groups (I-III) based on sequence homology, pharmacology and G protein coupling profiles [ 3 6 7 ] . Group II (mGluR2 and 3) and III (mGluR4, and 6 through 8) couple negatively to adenylate cyclase through activation of the G i/o family of G proteins [ 8 ] . Group I mGluRs (mGluR1 and 5) couple to multiple G proteins in native and heterologous systems, and have been observed to couple to G q/11 , G i/o and/or G s [ 9 10 11 12 13 14 15 ] . mGluRs appear to be important mediators of synaptic transmission in the brain.
In hippocampal slice preparations, γ oscillations can be triggered by high frequency tetanic stimuli, called post-tetanic γ oscillations [ 10 11 12 13 ] . In addition to post-tetanic γ oscillations, the γ oscillations also can be elicited by metabotropic glutamate receptor agonists, carbacol, or free extracellular Mg 2+ [ 18 19 ] . In this study, we report that γ oscillations can occur in a model of a clinical disorder, namely hyperthermia.
The findings described here demonstrate that the mammalian homologue of seven in absentia, Siah1a regulates the function of group I metabotropic glutamate receptors.
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