Words similar to metabolite
Example sentences for: metabolite
How can you use “metabolite” in a sentence? Here are some example sentences to help you improve your vocabulary:
Prostaglandin E 2 is a major cyclooxygenase metabolite of arachidonic acid which exerts diverse effects on vascular smooth muscle tone and epithelial solute transport via G-protein coupled receptors [ 1 2 ] . At least four distinct G-protein coupled PGE 2 receptors have been cloned: the EP 1 , EP 2 , EP 3 , and EP 4 [ 1 ] . Pharmacological studies suggest PGE 2 relaxes vascular smooth muscle through two of these receptors, the EP 2 and EP 4 receptors, which couple to cyclic-AMP generation [ 3 ] . In contrast, PGE 2 constricts other vascular smooth muscle through EP 3 receptors which inhibit cAMP generation via G i or EP 1 receptors which increase Ca 2+mobilization [ 3 ] . Although both EP 2 and EP 4 receptors relax smooth muscle, EP 2 receptors are uniquely sensitive to the agonists butaprost and AH13205 [ 3 4 ] . Previous studies have shown that PGE 2 increases the cAMP concentration in many tissues including kidney, intestine and uterus, but the relative contribution of EP 2 versus EP 4 receptors to these effects is incompletely defined [ 5 6 ] . Recent studies in mice with targeted disruption of these receptors have suggested an important role for EP2 receptor in regulating systemic hemodynamics.
Both residual SVS and its in situ -generated metabolite SVS-OH were detected in the mouse plasma as early as 10 min after gavage administration of 100 mg/kg of SVS (the shortest sampling interval).
Except for the demethylation of codeine (methylmorphine) to its active metabolite, their metabolic pathways do not become saturated.
In each brain site examined (except the cerebellum), the major phytoestrogen metabolite was equol and there were relatively low levels of daidzein and genistein.
Because the systemic and pulmonary vasculatures can both contribute to plasma NO metabolite levels, if NOS was downregulated in the systemic circulation as suggested by Toporsian et al.
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