Words similar to metabolite
Example sentences for: metabolite
How can you use “metabolite” in a sentence? Here are some example sentences to help you improve your vocabulary:
Except for the demethylation of codeine (methylmorphine) to its active metabolite, their metabolic pathways do not become saturated.
A high prevalence of 3q amplification has been reported in many studies on tobacco-associated cancers, including those of the lung, cervix and esophagus [ 11 13 14 15 16 17 ] . We and others have shown that PIK3CA is a candidate oncogene at 3q in these tumors [ 12 18 19 ] . Interestingly, PI3K pathway has been suggested to play a role in modulating the effects of benzopyrene, a tobacco-derived carcinogen, and its metabolite, anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-terahydrobenzopyrene [ 20 ] .
Pyridine-2,6-bis(thiocarboxylic acid) (pdtc) is an iron-regulated metabolite produced by certain pseudomonads that is highly reactive towards metals by virtue of a pair of thiocarboxylate groups and ring nitrogen that combine to form a non-specific, high affinity, tri-dentate ligand (Figure 1) [ 1 2 ] . The formation constants for Co, Cu, and Fe complexes of pdtc were determined to be greater than 10 33 [ 3 ] . Uptake studies using 59Fe showed that addition of pdtc to the growth medium of two different pdtc-producing pseudomonads increased the efficiency of iron uptake by 20% [ 1 ] . The contribution of pdtc to iron uptake may be due to the fact that the copper complex of pdtc (Cu:pdtc) has the ability to reduce both soluble and mineral forms of ferric iron) [ 1 ] . Not surprisingly, in light of its high affinity for essential metals, pdtc also exhibits antimicrobial activity [ 4 ] .
Such functions may include metabolite permeation.
Similarly as described in the clinical trials, the early animal studies reported data supportive of the initial findings [ 1 4 5 6 33 34 ] . These results however, were not substantiated in later studies in rodents, where SVS had no or little effect on bone mineral density [ 26 ] . However, none of the studies has verified the actual presence of the active SVS-OH metabolite in the animal serum, as shown in this study.
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