Words similar to metabolite
Example sentences for: metabolite
How can you use “metabolite” in a sentence? Here are some example sentences to help you improve your vocabulary:
[ 33 ] DNA synthesis inhibition is mediated by the binding of the active 5-FU metabolite 5-fluoro-2'deoxyuridine - 5-monophosphate (F-dUMP) to the enzyme thymidylate synthetase (TS).
Intestinal calcium absorption is increased after feeding a low calcium diet or under conditions of increased calcium needs, such as during growth, via a parathyroid hormone (PTH)-vitamin D mediated process [ 3 ] . A lowering of serum calcium levels stimulates the secretion of PTH that then activates the renal conversion of inactive 25-hydroxyvitamin D to the active hormonal metabolite 1,25-dihydroxyvitamin D. At the intestine, 1,25-dihydroxyvitamin D, acting through a nuclear receptor, stimulates transcription of vitamin D-mediated genes, including calbindin D, involved in calcium transport thereby acting as the primary hormonal regulator of active intestinal calcium transport [ 3 ] . It is thus likely that any putative key molecular player in calcium absorption, such as CaT1 or ECaC1, should be a prime target for hormonal regulation by 1,25-dihydroxyvitamin D. However, to date, neither CaT1 nor ECaC1 expression has been shown to be related to serum 1,25-dihydroxyvitamin D or vitamin D status [ 10 16 ] .
The elongase Elovl2 may contain an SRE, and therefore be under the transcriptional control of SREBP [ 35 ] ). Due to observations in the metabolite data, which suggests a repression of elongase activity, the dietary regulation of Elovl2 and Elovl3 was focused on.
In any case, the demonstrated effect of 1,25-dihydroxyvitamin D on CaT1 mRNA shown here in Caco-2 cells is consistent with the idea that the active metabolite of vitamin D could increase the number of CaT1 calcium transporters in the plasma membrane and could therefore be responsible for the higher rates of calcium influx seen across the brush border membrane in vitamin D-replete animals [ 9 27 ] thereby playing a key gatekeeper role in increasing the efficiency of intestinal calcium absorption and maintaining calcium homeostasis.
Its principal metabolite, normeperidine, has no analgesic properties of its own, has a longer half-life of about 6 hours, is renally excreted, and produces significant adverse effects when it accumulates.
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