Words similar to mecp

Example sentences for: mecp

How can you use “mecp” in a sentence? Here are some example sentences to help you improve your vocabulary:

The number of differentially regulated genes identified by these criteria, 49 with increased and 21 with decreased expression, is significantly higher than expected by random chance, but it is much lower than one would expect if MeCP2 had a crucial role as transcriptional repressor of all genes with methylated promoters.
Of the 47 unique genes with increased transcript levels in MeCP2 deficient cells, 32 are known to be expressed in brain (Table 1).
Mutations in MECP2, the gene that encodes the DNA binding protein MeCP2 (methyl-CpG binding protein 2), have been found in approximately 65-77% of Rett syndrome patients [ 7 8 9 10 ] . The functional consequence of MECP2 mutations resulting in Rett syndrome is loss of function.
To identify potential downstream targets of MeCP2 modulation, we have compared global gene expression patterns in four matched pairs of clonally derived mutant or wild-type MECP2-expressing fibroblast cell strains from girls with Rett syndrome, and in five wild-type and four mutant MeCP2-expressing lymphoblastoid cell lines, by hybridizing Affymetrix U95 (A-E) oligonucleotide microarrays.
The presence of growth retardation [ 17 ] , osteopenia [ 18 ] , and gastrointestinal abnormalities, however, suggest a potentially important role for MeCP2's function in the peripheral and autonomous nervous system and in other tissues.