Words similar to mecp

Example sentences for: mecp

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Allele-specific MECP2 transcript analysis
While MeCP2 is a ubiquitously expressed protein, its expression is highest in the brain, lung and spleen and less abundant in the kidney and heart [ 15 16 ] . It's cellular localization is also specific, with expression in neurons but not in glia.
Given the fact that the premature termination codons resulting from the frameshift mutations are all located in the 3' final exon of the MECP2 gene, preferential degradation of nonsense codon-containing transcripts would not be expected [ 24 ] .
It is instructive, however, that Tudor and colleagues compared global gene expression in a large number of wild-type and Mecp2 -null male mice and failed to identify striking changes in gene expression in the brain [ 30 ] .
While our initial matched fibroblast clonal comparisons identified numerous genes with consistent results that could be targets of MeCP2 modulation, verification of a small subset of these data by comparing additional clones not used on the GeneChip ®analysis revealed amazing inconsistency.