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Example sentences for: mec
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Those probes whose signal intensities were increased at least two-fold are summarized in Table 1. As Table 1shows, for a number of transcripts substitution with MeC or MeU may potentially augment hybridization signals more so than even DAP.
Naturally occurring analogs of purine and pyrimidine bases have been examined extensively for their ability to increase the thermodynamic stability of DNA:DNA and DNA:RNA duplexes [ 11 12 13 14 15 ] . Among these are 2-aminoadenine also known as diaminopurine (DAP), which is found in S-2L cyanophage DNA [ 16 ] , 5-methyl uracil (MeU), and 5-methyl cytidine (MeC).
In budding yeast, LCD1 Rad26physically interacts with MEC1 Rad3and is phosphorylated by MEC1 Rad3following DNA damage [ 36 37 ] . Likewise, human ATRIP Rad26physically interacts with ATR Rad3and also undergoes DNA damage-dependent phosphorylation by ATR Rad3 [ 35 ] . However, Rad26 is required for Rad3 kinase activity in fission yeast [ 18 ] , but LCD1 Rad26is not required for MEC1 Rad3kinase activity [ 38 ] while ATRIP Rad26is required for normal ATR Rad3expression [ 35 ] . Thus, the role of the Rad26-related proteins can differ among organisms.
In contrast, both of the modified pyrimidine triphosphates (MeC and MeU) tested resulted in a decrease in overall signal intensities for nearly all of the probes tested when compared against unmodified control samples (Figures 2D& 2E).
Finally, earlier studies have noted that methylation of cytosines (generating MeC) in ribopolynucleotides stabilizes duplexes to the same extent as substitution of thymine (MeU) for uracil [ 28 ] . Thus, although it is still surprising that MeC and MeU decrease hybridization intensities, it is not surprising that the magnitude of the effects generated by MeC and MeU residues are similar.
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