Words similar to lrr

Example sentences for: lrr

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1C) demonstrated that the caenorhabditis and drosophila putative proteins (hereafter named ceCCR4 and dCCR4, with assigned GenBank accession numbers AY043268 and AY043267, respectively; Table 1) also possess, in their N-terminal region, a LRR motif related to that of the yCCR4 protein (Fig.
Interestingly, although their C-terminal regions display significant similarity with the yCCR4 C-terminus (37%), none of these two proteins possesses a LRR domain (see Fig.
In fact, they contain the central LRR plus C-terminal region of yCCR4, but they lack its N-terminus (residues 1-350).
This region can, by itself, activate transcription when targeted to the DNA via a heterologous DNA-binding domain [ 5 ] . On the other hand, the LRR plus C-terminal region of yCCR4 cannot mediate transcription activation, but is involved in protein-protein interactions [ 5 ] . The yCCR4 LRR is necessary for the binding of several components of the CCR4-NOT complex, including yPOP2 -and mCAF1- [ 11 ] , yDBF2 [ 2 ] , yCAF4 and yCAF16 [ 8 ] , and deletion of the yCCR4 N-terminus does not impair these associations.
Conservation of the yCCR4 LRR plus C-terminus, together with the absence of its N-terminus in the CCR4 proteins of animals, could be interpreted along two lines.