Words similar to lrr
Example sentences for: lrr
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The drosophila and caenorhabditis proteins were characterized from matching genomic clones (accession number AE003746 and Z68753, respectively) in which we identified a similar LRR domain 20 kb and 4 kb, respectively, upstream of the exons for the yCCR4-like C-terminus.
Along this line, CCR4-specific conserved residues may be important for the setting of such a specificity, whereas the presence -or not- of a LRR domain may determine different associations for these proteins, possibly responsible for differences in cellular localization or in enzymatic activity.
This region can, by itself, activate transcription when targeted to the DNA via a heterologous DNA-binding domain [ 5 ] . On the other hand, the LRR plus C-terminal region of yCCR4 cannot mediate transcription activation, but is involved in protein-protein interactions [ 5 ] . The yCCR4 LRR is necessary for the binding of several components of the CCR4-NOT complex, including yPOP2 -and mCAF1- [ 11 ] , yDBF2 [ 2 ] , yCAF4 and yCAF16 [ 8 ] , and deletion of the yCCR4 N-terminus does not impair these associations.
4), thus indicating that m.nocturnin does not interact with hCAF1 or hPOP2, as expected from the absence of an LRR domain in this protein.
1C) demonstrated that the caenorhabditis and drosophila putative proteins (hereafter named ceCCR4 and dCCR4, with assigned GenBank accession numbers AY043268 and AY043267, respectively; Table 1) also possess, in their N-terminal region, a LRR motif related to that of the yCCR4 protein (Fig.
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