Words similar to lrp

Example sentences for: lrp

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In addition, LRP6 has been reported to bind Wnt-1 and to associate with Fz in a Wnt-dependent manner [ 8 ] . Taken together, these results support a co-receptor model: upon exposure to Wnts, LRP5 or LRP6 forms a complex with Wnt and Fzs, transducing the Wnt signal downstream to stabilize cytoplasmic β-catenin.
Alternatively, however, it is possible that Wnt/Wg can signal through LRP/Arr in the absence of Fzs.
To investigate whether these constructs can also function in S2 cells and whether their activities can synergize with Wg, we transferred LRP6 and LRP6ΔN into the Drosophila expression vector pPacPL (Figure 4A) and tested them alone and with various combinations of Wg and DFz2 in S2 cells (Figure 4B).
If the carboxyterminus of LRP6 can interact with Axin independently of DFz2 and Dsh, it might reduce the cytoplasmic level of Axin and help stabilize β-catenin.
However, it was recently reported that no direct interactions between Arrow and Wg were detected [ 22 ] . It is possible that LRP aminoterminus is required for interacting with another extracellular protein rather than Wnt and Fz.