Words similar to lrp

Example sentences for: lrp

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LRPs have been shown to bind to Wnt/Wg through the first and second EGF repeats of their extracellular domain [ 11 ] . Our unpublished work in mammalian cells and results from others [ 11 13 ] demonstrate that the expression of LRP6 or an aminoterminal truncation mutant (LRP6ΔN), which should no longer bind to Wnt, can activate the Wnt signaling pathway.
Signaling via LRP6ΔN, however, while dependent on Arm as expected, is not dependent on Dsh or DFz2, as judged by the use of dsRNAi (Figure 5A).
Again, Arr dsRNAi markedly inhibited signaling by Wg and DFz2, but no inhibition was observed in the presence of the LRP6 plasmid, implying the LRP6 could substitute for Arr in these synergistic events.
Since we have been unable to measure Arr or LRP proteins directly in transfected cells, we cannot distinguish between more efficient expression or greater inherent activity of the LRPs as an explanation of the different effects of LRPs and Arr.
Recently, it was reported that two single-transmembrane proteins of the LDL-receptor-related proteins (LRP) family, LRP5 and LRP6, are also involved in receiving the Wnt signal [ 7 8 9 ] . Drosophila Arrow (Arr), which is homologous to murine and human LRP5 and LRP6, was shown to be essential for Wg signaling.