Words similar to lrp

Example sentences for: lrp

How can you use “lrp” in a sentence? Here are some example sentences to help you improve your vocabulary:

We show that DFz2 and LRP/Arr cooperate with Wg to activate the signaling pathway.
We conclude that Wnt/Wg signaling requires functional interactions of both LRP/Arr and Fz classes of receptors, and the cytoplasmic component Dsh.
Consistent with this, it has been demonstrated that Dickkopf-1 inhibits Wnt/β-catenin signaling by binding to LRP5 or LRP6 to prevent Wnt-receptor complex formation [ 10 11 12 ] .
However, it was recently reported that no direct interactions between Arrow and Wg were detected [ 22 ] . It is possible that LRP aminoterminus is required for interacting with another extracellular protein rather than Wnt and Fz.
In addition, LRP6 has been reported to bind Wnt-1 and to associate with Fz in a Wnt-dependent manner [ 8 ] . Taken together, these results support a co-receptor model: upon exposure to Wnts, LRP5 or LRP6 forms a complex with Wnt and Fzs, transducing the Wnt signal downstream to stabilize cytoplasmic β-catenin.