Example sentences for: low-dose

How can you use “low-dose” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The doxazosin arm of ALLHAT was stopped early, due to a doubling of the incidence of congestive heart failure in this group, as compared to the low-dose chlorthalidone arm [ 1 ] . Prior to this publication, there had been no obvious suggestion of a mechanism by which peripheral alpha-1 antagonists in general or doxazosin in particular would be inferior to chlorthalidone or would specifically cause CHF.

  • To maximize their epidemiological relevance, low-dose challenge experiments should therefore involve challenge doses that reflect transmission probabilities at the upper end of the spectrum.

  • Thus, the single low-dose challenge design is not feasible, or at least not practical, to assess the efficacy of a vaccine or other preventive interventions in animals.

  • In contrast, in single low-dose challenge experiments with the same number of animals per group the statistical power is only 15%.

  • The belief that experiments involving realistically low challenge doses require unfeasibly large numbers of animals has prevented the development of low-dose challenge models.


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