Words similar to low-copy
Example sentences for: low-copy
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To mark the regions of low-copy repeats in human 15q11-q13, we utilized a probe derived from the donor locus of a major component of the PWS/AS breakpoint duplication clusters, PAC clone pDJ-778A2 which contains a significant portion of the HERC2 gene in 15q13 [ 33 ] . In addition, we selected probes corresponding to sites distal to the PWS/AS domain flanking a large inverted-duplicated 15 (inv dup(15)) supernumerary marker chromosome [ 23 ] . Specifically, probe RPCI-11-88O16 (abbreviated RP11-88O16) was selected for FISH analysis because it lies distal to the inversion-duplication event breakpoint and is linked to STS marker D15S1010 [ 23 24 ] . Upon reaching the PTR inversion breakpoint interval with probe RP11-40J8, flanking BACs were chosen from the November 2002 human genome assembly to establish the extent of the interval and define the boundaries of the interval.
Two low-copy families belonging to the same clade are Osr32 and Osrs6/Rire3 [ 27] (Figure 2).
Nine additional low-copy families identified by earlier workers are Osr47/Tos9 , Osr48/Tos10, Osr49/Tos11, Osr50/Tos13, Osr54/Tos19, Osr55/Tos20, Osr57/Rtr3, Osr58/Rrt5 , and Osr59/Rrt8.
[ 13 ] . HPV was not detected by the assay in basal/parabasal cells of (non-condylomatous) CIN I lesions (> 30 examined; unless HPV-16 positive [ 2 ] ) suggesting low-copy number episomal HPV was not detectable and indicating a limit to the sensitivity of the assay.
If this is the case, then punctate signal detected in carcinomas and high-grade CIN lesions may only represent integration of multiple copies of HPV at sites within the genome, and low-copy episomal (or integrated) DNA may remain sub-threshold on archival FFPE samples.
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