Words similar to lineage
Example sentences for: lineage
How can you use “lineage” in a sentence? Here are some example sentences to help you improve your vocabulary:
M6P/IGF2R is normally imprinted in mice with only the maternal copy of the gene being expressed [ 41 ] . In contrast, both copies of the M6P/IGF2R are expressed in humans because genomic imprinting at this locus was lost in the primate lineage approximately 75 million years ago [ 42 ] . Importantly, restoration of biallelic M6P/IGF2R expression in mice results in a marked reduction in offspring weight late in embryonic development that persists into adulthood [ 43 ] . This demonstrates that M6P/IGF2R allelic loss or haploid insufficiency markedly enhances cell proliferation and/or survival during fetal development.
Much progress has been accomplished in determining the molecular steps that lead to a better understanding of murine T cell progenitor commitment and selection of the functional repertoire, which has gained important insights into mechanisms of CD4/CD8 lineage commitment (reviewed in 31).
Despite the lineage effect in levels of conservation in the D. willistoni genome, the median length of conserved coding or non-coding segments generally decreases with increasing divergence time as expected (Table 4).
In fact, it may be possible to take advantage of these unusual patterns of molecular evolution in the D. willistoni lineage to dissect regions of the Drosophila genome under different levels of functional constraint.
The following files are available with the online version of this article: expression datasets of the cell culture and xenograft profiles as a tab-delimited text file (Additional data file 1); a spreadsheet file including extra data, such as the scale-normalized means prior to quantile normalization, p -values from the 'present' test, a sheet of data from 60 control probe-sets on the Affymetrix chips, and data from the mouse lung tissue control profile (Additional data file 2); the search results for significantly enriched classes for GO annotation (Additional data file 3) and for MeSH term literature associations (Additional data file 4) for genes found to significantly differ at p < 0.01, fold change > 2 between tumors and cell cultures for a given cell line; the values used in the classifications of cell culture lineage using xenograft tumor profiles, together with the classification results, which correctly predicted the lineage of all six cell culture profiles, as an Excel spreadsheet (Additional data file 5).
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