Example sentences for: lgic
How can you use “lgic” in a sentence? Here are some example sentences to help you improve your vocabulary:
LGIC receptors are found in both the peripheral and central nervous systems.
Mutagenesis studies have identified the interaction of amino acids W89 and R91 in the binding of 5-HT 3 R ligands [ 24 23 ] . Studies conducted in our laboratory have identified three additional putative binding site residues (Y140, Y142, and Y152) [ 25 ] . W89 and R91 are present in a conserved region of LGIC receptors often referred to as loop D [ 24 26 ] . Similarly, Y140, Y142 and Y152 are located in the region homologus to E loop region of nicotinic AchR.
The cysteine-loop family of ligand gated ion channels (LGIC) is comprised of receptors with pentameric quaternary structure and at least two ligand binding sites present at the subunit interfaces [ 1 2 ] . This receptor family is characterized by the presence of a critical disulfide loop structure within the binding site and an integral ion selective channel.
This structure is supported by site-directed mutagenesis data [ 25 ] as well as structural predictions obtained from other LGIC receptors [ 31 ] . The recent determination of the structure of a nicotinic acetylcholine binding protein [ 27 ] that shares significant homology with the LGIC family also supports a loop structure in this part of the protein.
The first subunit of the 5-HT 3 R was cloned in 1991 [ 7 ] . The sequence of this subunit was shown to be highly homologous to LGIC receptors and thus identified the 5-HT 3 R receptor as another member of this superfamily [ 7 8 9 ] . Similar to other LGIC receptors, more than one subtype has been identified.
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