Words similar to lg
Example sentences for: lg
How can you use “lg” in a sentence? Here are some example sentences to help you improve your vocabulary:
In contrast to the results with the transient transfections with the CYP response elements, CYP2B6 expression was decreased to a comparable extent by androstanol, LG1069, and the combination of both ligands.
On the tandem CYP2B10 elements, LG1069 does not have a stimulatory effect on its own and does not decrease the inhibitory effect of androstanol, but it does increase response to TCPOBOP.
CYP2B6 expression was increased by TCPOBOP, as expected, and this response was blocked by LG1069 treatment.
For example, it is possible that the inhibitory effect of LG1069 in the stable CAR expressing cell line is based on the sequestration of limiting amounts of RXR into ligand-dependent homodimers, as has been suggested in previous studies using primary hepatocytes [ 17 ] . However, similar effects were observed with the relatively large amounts of RXR used for the biochemical studies or with the transient transfections, which relied on cotransfected RXR.
In more detailed dose response studies, 100 nM LG1069 decreased the inhibitory effect of androstanol by as much as 70% and had an even stronger effect on TCPOBOP activation (Fig.