Words similar to leukemogenic

Example sentences for: leukemogenic

How can you use “leukemogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:

In normal erythroid cells it acts as a repressor of the β-globin gene [ 22 23 ] . However, BP1 was also expressed in 47% of the adult and 81% of the pediatric acute myeloid leukemia patients we examined, and its overexpression increased the leukemogenic potential of K562 cells in vitro [ 11 ] . Molecular analysis revealed that BP1 expression is required for the survival of K562 leukemia cells, suggesting that BP1 might be part of an anti-apoptotic pathway (Davenport GJ, Fu S, Haga SB, Do K, Stevenson H, Pinzone J, Chase MB, Berg PE, unpublished data).
Our previous studies showed that BP1 is also expressed in leukemia and has characteristics of an oncogene: in acute myeloid leukemia, BP1 is highly expressed in the bone marrow of 63% of patients overall, with a preponderance of expression in pediatric patients [ 11 ] . When overexpressed in a leukemia cell line (K562), BP1 increased the ability of cells to grow in soft agar, an indicator of leukemogenic potential, up to 45-fold [ 11 ] . Consistent with a possible oncogenic role for BP1 in breast cancer was the observation that its expression was correlated with the ability of breast cancer cell lines to cause mammary tumors in mice.