Example sentences for: laminins

How can you use “laminins” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For example, cadherin 13 ( CDH13 ), versican ( CSPG2 ), collagen 8A1 ( COL8A1 ), collagen 12A1 ( COL12A1 ), P4HA2 (encoding a procollagen-modifying enzyme) all showed relatively low expression in the genital skin fibroblasts of normal males, whereas tenascin XB ( TNXB ), nidogen 2 ( NID2 ), laminins ( LAMA3 , LAMA4 ) and tissue inhibitor of metalloproteinase 1 ( TIMP1 ) all showed relatively high expression levels compared to AIS-derived fibroblasts (Figure 2).

  • Nidogen is a basement membrane protein composed of three globular domains G1-G3 and two linking sequences; domain G1 is joined to domain G2 through a flexible link and domain G2 is connected to domain G3 by a rod-like element consisting of EGF-like modules [ 47 ] . Nidogen1 is an important structural component of tertiary complexes with other such extracellular components as laminins, collagen IV, perlecan, and fibulins [ 48 ] . Fibulin-1C binds to nidogen1 through domain G2 of nidogen [ 48 ] . The nidogen binding site of fibulin-1C includes the type II EGF-like modules 6-9 and the carboxyl-terminal domain [ 42 ] .

  • This led Stemple into studying muscular dystrophy because laminins are involved in the human disease.

  • Among the genes that are important in notochord development are those that encode laminins.

  • This is based on aggregation assays showing different time courses, additive dose response relationships, and differential co-localization of the dystrophin complex, and on biochemical observations indicating the lack of requirement for MuSK, and the lack of tyrosine-phosphorylation of receptors during LN1 but not agrin induced aggregation [ 1 2 4 ] . The very minimal receptor aggregation seen in agrin deficient mice certainly argues that laminins are not sufficient to trigger receptor aggregation [ 5 ] . More recently we have shown that agrin and LN1 induced aggregates can also be differentiated on the basis of the ultrastructural arrangement of receptors within aggregates [ 6 ] .


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