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Example sentences for: lamins
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Alternatively, it could be that lamins or other nuclear proteins have a phosphorylated epitope also found on NFs.
The Drosophila mutations Mushroom body defect (a gene involved in the proliferation of neuronal precursor cells) and quick-to-court (a mutation that causes elevated sexual behavior) lie in two tissue-specifically expressed coiled-coil proteins of unknown function [ 20 21 ] . In humans and mouse models, specific point mutations in nuclear lamins are the cause for autosomal Emery-Dreifuss muscular dystrophy [ 22 23 ] .
The calculated molecular weights of lamins A, B and C are approximately 74, 66, and 65 kDa, respectively; therefore, it seems most likely that lamins, NF-H, and GFAP all share a common motif that, when phosphorylated, is recognized by SMI-31 and RT-97 mABs.
In a recent search of all publicly available plant sequences, including the full Arabidopsis genome, no homologs of lamins were found ( [ 33 ] and Meier, unpublished results).
Numerous putative phosphorylation motifs were identified in the amino acid sequences of NF-H, GFAP and nuclear lamins A, B, and C when analyzed by the NetPhos server, including a single tyrosine kinase motif, LNDRFAG