Words similar to lamins
Example sentences for: lamins
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Besides the presence of extended coiled-coil domains, the FPP family members have no sequence similarity to the vertebrate lamins.
Our preliminary observations indicate that some of the intranuclear inclusions containing Rab24(D123I) are immunoreactive for lamins, while those outside the nucleus are not (Fig.
Although these nuclear epitopes appear similar to nuclear speckles, the latter have not been reported as IF-associated structures, but rather storage sites of RNA processing proteins (see Sanford 2002, for a current, brief review [ 5 ] ). However, as it is know that lamins are involved in nucleo-skeletal organization [ 23 ] and organization of DNA replication sites [ 4 ] , it would not be unexpected to find lamins associated with nuclear speckles, perhaps as structural organizers.
A subgroup of intermediate-filament proteins are the nuclear lamins, which are involved in attaching chromatin to the nuclear envelope and have recently been implicated in inherited human diseases [ 5 6 ] . Besides structural proteins of the cytoskeleton, the motor proteins that interact with them also contain coiled-coil motifs.
In support of this, a search for phosphorylation motifs among NF-H, GFAP and lamins A, B, and C revealed a single, high probability tyrosine site that occurs once on each of these proteins (Figure 3), further suggesting the possibility that this site constitutes or is contained within the epitope recognized by these two antibodies.