Words similar to lamins

Example sentences for: lamins

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The nuclear lamins contain short, conserved sequences flanking the lamin rod domain, which are phosphorylated by cdc2 kinase [ 41 ] . The 90 amino acid PACT domain, which immediately follows the coiled-coil domain of the related proteins pericentrin and AKAP450 and two uncharacterized coiled-coil open reading frames from Drosophila and Schizosaccharomyces pombe , confers centrosomal localization [ 19 ] . A conserved domain of ca. 50 amino acids was found in several Golgi-associated large coiled-coil proteins.
Alternatively, it could be that lamins or other nuclear proteins have a phosphorylated epitope also found on NFs.
Lamins assemble into a higher order structure and truncations may interfere with this assembly.
Because of the association of phosphorylated lamins with DNA replication and the cell cycle [ 8 ] , and the sharing of phosphoepitopes among lamins, NFs, and GFAP, it seems most probable that the nuclear epitopes revealed in neuroblastoma and glioma cells by SMI-31 and RT-97 are contained on lamin B.
Therefore it is possible that this sequence constitutes or contains the epitope recognized by the SMI-31 and RT-97 mABs, and may account for the cross-reactivity of these antibodies with respect to NF-H, GFAP, and lamins.