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Example sentences for: lamins
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Although these nuclear epitopes appear similar to nuclear speckles, the latter have not been reported as IF-associated structures, but rather storage sites of RNA processing proteins (see Sanford 2002, for a current, brief review [ 5 ] ). However, as it is know that lamins are involved in nucleo-skeletal organization [ 23 ] and organization of DNA replication sites [ 4 ] , it would not be unexpected to find lamins associated with nuclear speckles, perhaps as structural organizers.
A subgroup of intermediate-filament proteins are the nuclear lamins, which are involved in attaching chromatin to the nuclear envelope and have recently been implicated in inherited human diseases [ 5 6 ] . Besides structural proteins of the cytoskeleton, the motor proteins that interact with them also contain coiled-coil motifs.
In a recent search of all publicly available plant sequences, including the full Arabidopsis genome, no homologs of lamins were found ( [ 33 ] and Meier, unpublished results).
The nuclear lamins contain short, conserved sequences flanking the lamin rod domain, which are phosphorylated by cdc2 kinase [ 41 ] . The 90 amino acid PACT domain, which immediately follows the coiled-coil domain of the related proteins pericentrin and AKAP450 and two uncharacterized coiled-coil open reading frames from Drosophila and Schizosaccharomyces pombe , confers centrosomal localization [ 19 ] . A conserved domain of ca. 50 amino acids was found in several Golgi-associated large coiled-coil proteins.
In support of this, a search for phosphorylation motifs among NF-H, GFAP and lamins A, B, and C revealed a single, high probability tyrosine site that occurs once on each of these proteins (Figure 3), further suggesting the possibility that this site constitutes or is contained within the epitope recognized by these two antibodies.
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