Words similar to lamin
Example sentences for: lamin
How can you use “lamin” in a sentence? Here are some example sentences to help you improve your vocabulary:
In this model, lamin A/C is necessary for the appropriate expression of tissue-specific genes.
The complete SKP2 cDNA or a mutant lacking the F-box (SKP2-ΔF) were cloned into a modified pcDNA3 plasmid providing an N-terminal Myc epitope tag and the human lamin B leader sequence.
As specialized proteins of the intermediate filament protein family, lamin A/C is found at the inner nuclear membrane where it forms a scaffold that interacts with a network of membrane bound and nucleoplasmic proteins in addition to chromatin [ 3 4 5 ] . Mutations in the gene encoding the nuclear membrane protein emerin produce autosomal recessive Emery Dreifuss Muscular Dystrophy, a disorder that phenotypically overlaps the neuromuscular and cardiovascular features seen with lamin A/C mutations [ 6 ] . Consistent with this, lamin A/C directly binds emerin [ 7 8 ] . Lamins A and C are broadly expressed in many different cell types and are primarily expressed in terminally differentiated cells.
The nuclear lamins contain short, conserved sequences flanking the lamin rod domain, which are phosphorylated by cdc2 kinase [ 41 ] . The 90 amino acid PACT domain, which immediately follows the coiled-coil domain of the related proteins pericentrin and AKAP450 and two uncharacterized coiled-coil open reading frames from Drosophila and Schizosaccharomyces pombe , confers centrosomal localization [ 19 ] . A conserved domain of ca. 50 amino acids was found in several Golgi-associated large coiled-coil proteins.
The lamin B-SKP2 cassette was removed and cloned into the pADTRACK1 shuttle vector.
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