Words similar to knockout
Example sentences for: knockout
How can you use “knockout” in a sentence? Here are some example sentences to help you improve your vocabulary:
This contrasts with the lack of conservation of Tnfrh1 , and the species-specific imprinting of at least one placental lactogen gene [ 20 ] . Of more immediate interest is the biological function of Tnfrh1 , which will need to be determined by knockout experiments.
CFTR regulation of ENaC has been described in the colon in humans [ 37 ] and in cftr knockout mice [ 37 ] . Co-localization of CFTR and ENaC suggests that direct protein-protein interactions allow CFTR to closely regulate the activity of this channel [ 39 40 ] . Our results suggest that knockout of CFTR leads to an analogous increase in expression and function of IBAT.
In the liver, intestine, adipose, and mammary gland, the cytoplasmic form synthesizes acetyl CoA for lipogenesis [ 46 ] . It is regulated by SREBP-1a, -1c- and -2, as well as SP1 and SP3 binding to GC-boxes; the promoter also contains an E-box [ 47 ] . It is down regulated with fasting, and induced with re-feeding; such dietary regulation does not exist in SREBP-1 knockout mice [ 48 ] . More generally, acyl CoA synthase is reported to be PPARα-activated [ 49 ] . The observed down regulation is consistent with less acetyl CoA available for the ACC reaction, as well as a plethora of other reactions.
ERα (αERKO) and ERβ knockout (βERKO) female mice possess a normally developed reproductive tract and maintain expression of the opposite ER [ 22 ] . The αERKO female is infertile and exhibits a hypoplastic uterus that is refractory to estrogens.
Comparison of populations founded by either wild-type individuals or those with a single gene ‘knockout’ revealed much higher levels of phenotypic variation in populations derived from the ‘knockouts’.
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