Example sentences for: knockout

How can you use “knockout” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A recent cardiac muscle specific gp130 knockout model develops normally [ 60 ] . Whereas, non-tissue specific gp130 knockout results in hypotrophic cardiac muscle apparent by E15.

  • In some differentiating cell types, changes in both gene transcription and proliferation are regulated by the same transcription factor [ 1 2 3 4 5 6 7 8 9 ] . CCAAT/Enhancer Binding Protein alpha (C/EBPα) is a transcription factor that is required for the differentiation of a number of tissues [ 10 11 12 13 14 15 16 17 18 ] . Mice homozygous for C/EBPα null alleles have severe defects in tissues involved in metabolic homeostasis [ 19 20 21 ] . Cellular proliferation is elevated in the liver of these knockout mice [ 22 ] suggesting that C/EBPα blocks proliferation in vivo.

  • MAdCAM-1 has also been detected at high levels on colonic lamina propria venules from mice with hapten induced colitis [ 14], mice injected with TNF-α [ 15], or colitic IL-2 knockout mice [ 16].

  • Specific genes now can be routinely over-expressed as transgenes, or eliminated by gene targeting, which creates a “knockout” (Smithies 1993; Wassarman and DePamphilis 1993).

  • Prudie's betting you will, in the future, pay closer attention to knockout ladies in public places.


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