Words similar to knockout

Example sentences for: knockout

How can you use “knockout” in a sentence? Here are some example sentences to help you improve your vocabulary:

Specific genes now can be routinely over-expressed as transgenes, or eliminated by gene targeting, which creates a “knockout” (Smithies 1993; Wassarman and DePamphilis 1993).
A recent cardiac muscle specific gp130 knockout model develops normally [ 60 ] . Whereas, non-tissue specific gp130 knockout results in hypotrophic cardiac muscle apparent by E15.
The introduction of LacZ into specific genes during the generation of knockout mice has demonstrated that such an approach can be successful [ 8, 9].
Evidence for gustducin's role in bitter taste came from knockout studies, in which a targeted deletion of α-gustducin resulted in mice with a reduced sensitivity for bitter compounds [ 10].
MCF7 cells are sensitive to rapamycin analogs in the low nM range [ 33 ] . A potential problem with the use of rapamycin and its analogs is that some tumors are intrinsically resistant to its effects [ 33 34 ] . Resistance in mammalian cells has been associated with decreased expression of 4EBP-1 [ 35 ] , mutations in the ATM protein [ 36 ] , and low level expression of p27 Kip1due to enhanced turnover of the protein [ 37 ] . In addition, it has been demonstrated that fibroblasts from p27 Kip1knockout mice are more resistant to the effects of rapamycin than normal cells [ 37 ] . Thus p27 Kip1is an important mediator of cell growth inhibition in response to rapamycin.