Example sentences for: knockout

How can you use “knockout” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Knowing the precise location of breakpoints in RI lines also makes it possible to map modifier loci of mutations by making and phenotyping a set of different F1 crosses made between inbred carrier stock (for example, a knockout carried on a C57BL/6 background) and fully typed RI lines.

  • per1 single knockout mice and mice expressing a non-functional PER2 protein both exhibit subtle differences from wild type in the homeostatic rebound after SD [ 54 ] , an observation compatible with the hypothesis that these genes are correlates of sleep homeostasis.

  • More problematic is the interpretation of results obtained with knockout models.

  • The NR family contains two related ERs (ERα and ERβ) that conform to the typical three domain NR structure and share extensive sequence homology in the DBD and LBD region [ 20 21 ] . Analysis of the function of the individual ERs in mouse knockout models suggests that the major proliferative effects of estrogen are mediated by ERα and not by ERβ, which seems to play an inhibitory role in proliferation in some studies [ 22 23 ] . The ligand-binding properties of the ERs are different, with ERβ often exhibiting stronger binding to plant-derived phytoestrogens [ 24 ] . More importantly, the ERs exhibit isoform-specific effects on gene expression.

  • That report could deliver a knockout blow to Clinton.


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