Example sentences for: knockdown

How can you use “knockdown” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • RNA interference (RNAi), mediated by short interfering double-stranded RNA molecules (siRNA or dsRNA), is now recognized as a major mechanism of post-transcriptional gene silencing (PTGS) in essentially all eukaryotes [ 16 ] . Recently, the technique has been successfully applied to cultured mammalian cells, whereby introduction of 21-nucleotide long synthetic dsRNA molecules corresponding to specific mRNA sequences effectively and specifically degraded the cognate mRNAs and abrogated the expression of the corresponding proteins [ 17 18 ] . This prompted us to test a similar approach to knockdown PfPP1 function in the erythrocytic P. falciparum stages.

  • Post-transcriptional gene silencing using synthetic short interfering RNA (siRNA) molecules has been recently used to ablate specific mRNAs and thus, produce phenotypic mutations in specific genes [ 16 17 ] . We have adopted this technology to knockdown specific gene products in RNA viruses that are obligatory intracellular parasites [ 18 ] . In the present study, we have successfully used a similar strategy to generate phenotypic PP1-deficient P. falciparum parasites.

  • As for those shrinking violets Matalin and Carville, Prudie has a hunch they have knockdown drag-out fights about their different affiliations.

  • 2004) using various methods including overexpression and gene knockdown (siRNA) approaches (Tadokoro et al.

  • 2002b) and the application of RNAi knockdown technology to study regeneration in planarians (Sanchez Alvarado and Newmark 1999; Newmark et al.


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