Words similar to knockdown
Example sentences for: knockdown
How can you use “knockdown” in a sentence? Here are some example sentences to help you improve your vocabulary:
As for those shrinking violets Matalin and Carville, Prudie has a hunch they have knockdown drag-out fights about their different affiliations.
Post-transcriptional gene silencing using synthetic short interfering RNA (siRNA) molecules has been recently used to ablate specific mRNAs and thus, produce phenotypic mutations in specific genes [ 16 17 ] . We have adopted this technology to knockdown specific gene products in RNA viruses that are obligatory intracellular parasites [ 18 ] . In the present study, we have successfully used a similar strategy to generate phenotypic PP1-deficient P. falciparum parasites.
2004) using various methods including overexpression and gene knockdown (siRNA) approaches (Tadokoro et al.
2002b) and the application of RNAi knockdown technology to study regeneration in planarians (Sanchez Alvarado and Newmark 1999; Newmark et al.
RNA interference (RNAi), mediated by short interfering double-stranded RNA molecules (siRNA or dsRNA), is now recognized as a major mechanism of post-transcriptional gene silencing (PTGS) in essentially all eukaryotes [ 16 ] . Recently, the technique has been successfully applied to cultured mammalian cells, whereby introduction of 21-nucleotide long synthetic dsRNA molecules corresponding to specific mRNA sequences effectively and specifically degraded the cognate mRNAs and abrogated the expression of the corresponding proteins [ 17 18 ] . This prompted us to test a similar approach to knockdown PfPP1 function in the erythrocytic P. falciparum stages.
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