Example sentences for: knock-out

How can you use “knock-out” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Comparing the phenotypes of Dazl1 and Dazap1 single and double knock-out mice may provide some clues to the significance of their interaction.

  • In addition, Skp2 knock-out cells do not accumulate E2F [ 21 ] and an E2F mutant unable to bind Skp2 is still ubiquitinated and unstable [ 21 ] . Thus, the basis of S phase destruction of E2F-1 remains unresolved.

  • There are two published reports of BLM knock-out mice: one strategy used a single deletion allele and found that the homozygous null mutants are embryonic lethals [ 4]; the second strategy used two different deletion alleles and recovered full sized, fertile compound heterozygote mice with an elevated incidence of cancer [ 5].

  • However, EGFP-cPLA 2 is functional since it dose-dependently catalyzes release of AA when expressed in cells that lack endogenous cPLA 2 , such as Sf9 cells [ 13 ] and immortalized mouse lung fibroblasts from cPLA 2 α knock-out mice [ 26 ] . In order to enhance AA release in cells containing endogenous cPLA

  • Additional studies, such as the construction and characterization of targeted knock-out mutants, will be needed to determine the roles of the proteins encoded by these genes in the survival of M. tuberculosis in human macrophages.


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