Words similar to knock-out
Example sentences for: knock-out
How can you use “knock-out” in a sentence? Here are some example sentences to help you improve your vocabulary:
In order to confirm the yeast database entry indicating that the MDN1 (YLR106C) gene is essential for viability in yeast, we performed tetrad analysis of the heterozygous midasin knock-out strain CMEY072(HE) (Mat a/α ura3-52/ura3-52 his3D1/his3D1 leu2-3_112/leu2-3_112 trp1-289/trp1-289; MDN1(4,14727)::kanMX4/MDN1) obtained from EuroScarf.
Hence the signaling mechanism, like that reported in normal myotubes and dysgenic myotubes expressing wt-α 1S , was Ca 2+entry independent [ 29 ] . We also expressed fs-α 1S in cultured myotubes from two available gene knock-out (KO) mice, lacking the endogenous β1a isoform of the skeletal muscle DHPR [ 30 ] and lacking RyR1 [ 31 ] . As shown in Fig.
There are two published reports of BLM knock-out mice: one strategy used a single deletion allele and found that the homozygous null mutants are embryonic lethals [ 4]; the second strategy used two different deletion alleles and recovered full sized, fertile compound heterozygote mice with an elevated incidence of cancer [ 5].
However, EGFP-cPLA 2 is functional since it dose-dependently catalyzes release of AA when expressed in cells that lack endogenous cPLA 2 , such as Sf9 cells [ 13 ] and immortalized mouse lung fibroblasts from cPLA 2 α knock-out mice [ 26 ] . In order to enhance AA release in cells containing endogenous cPLA
Additional studies, such as the construction and characterization of targeted knock-out mutants, will be needed to determine the roles of the proteins encoded by these genes in the survival of M. tuberculosis in human macrophages.
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