Example sentences for: knock-out

How can you use “knock-out” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Hence the signaling mechanism, like that reported in normal myotubes and dysgenic myotubes expressing wt-α 1S , was Ca 2+entry independent [ 29 ] . We also expressed fs-α 1S in cultured myotubes from two available gene knock-out (KO) mice, lacking the endogenous β1a isoform of the skeletal muscle DHPR [ 30 ] and lacking RyR1 [ 31 ] . As shown in Fig.

  • However, similar levels of p21 mRNA in the livers of wild-type and homozygous C/EBPα knock-out mice [ 22 ] argue against a physiologically significant contribution of C/EBPα to p21 gene transcription in the liver.

  • Additional studies, such as the construction and characterization of targeted knock-out mutants, will be needed to determine the roles of the proteins encoded by these genes in the survival of M. tuberculosis in human macrophages.

  • Supporting evidence for the involvement of IGF-II in the proliferative effect resulting from loss of M6P/IGF2R function comes from studies of M6P/IGF2R knock-out mice.

  • However, EGFP-cPLA 2 is functional since it dose-dependently catalyzes release of AA when expressed in cells that lack endogenous cPLA 2 , such as Sf9 cells [ 13 ] and immortalized mouse lung fibroblasts from cPLA 2 α knock-out mice [ 26 ] . In order to enhance AA release in cells containing endogenous cPLA


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