Words similar to kinetochores

Example sentences for: kinetochores

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Based on studies involving compounds that alter microtubular kinetics and induce both cell-cycle delay and aneuploidy, several groups have proposed that temporal perturbations during mammalian oocyte maturation (OM) predispose oocytes to aneuploidy [ 3 4 5 6 ] . In addition to faulty microtubule kinetics, perturbations during OM may also stem from abnormal function of centrosomes, kinetochores, spindle checkpoints proteins, the anaphase-promoting complex (APC), the securin-separin-cohesion complex proteins, and the proteasome [ 7 ] .
Separase is needed for inactivating cohesions and enabling sister chromatid separation [ 35 36 37 ] in both fission yeast [ 38 ] and mammalian cells [ 39 ] . Although differences have been reported among species [ 40 ] and cell types [ 41 ] , it appears that the majority of cohesion is removed from mammalian chromosomes during prophase and prometaphase; whereas, a lesser amount remains at kinetochores until anaphase onset.