Words similar to kinetochore-microtubule
Example sentences for: kinetochore-microtubule
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Abnormal chromosome segregation has been observed in mice lacking the Mad2 checkpoint protein [ 25 ] . The spindle checkpoint utilizes sensory proteins that detect kinetochore-microtubule tension and occupancy and transiently block anaphase until all of the chromosomes are properly attached to microtubules [ 16 26 27 ] . Although the mammalian spindle checkpoint appears to differ between mitosis and meiosis, the two meiotic divisions, and male and female germ cells [ 28 ] , anaphase subsequently follows stable kinetochore-microtubule attachments [ 17 29 ] in both vertebrate mitotic [ 30 ] and meiotic [ 31 ] cells.
The origin of single, unpaired chromatids in MII oocytes has been proposed to result from premature separation of sister chromatids prior to anaphase I [ 56 57 ] . The possibility exists that both SC and aneuploidy may have originated from PCS of homologues and sister chromatids during the MAT of meiosis I. Upon removal of MG-132 from the culture media during meiosis I and the subsequent resumption of OM and proteasomal activity, faulty kinetochore-microtubule attachment accompanied by degradation of cohesion proteins could conceivably lead to PCS of homologues and sister chromatids.