Example sentences for: junb

How can you use “junb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This was somewhat surprising, since MAPK pathways do not activate JunB [ 29] and in some systems JunB antagonizes transcriptional activation by c-Jun [ 30].

  • Pretreatment of mice with RU 486 caused significant increases in hepatic levels of JunB and mdm2 (Fig 2).

  • The protein product of this gene is a member of the activating protein-1 (AP-1) family [ 19 ] , which upon binding to either c-fos or fos B protein form a complex that have high affinity to AP-1 binding concensus sequence [ 20 ] . A wide variety of chemicals, including growth factors, and tumor promotors increase the expression of this gene in various cell types [ 21 ] . Compared to untransfected keratinocytes, JunB-transfected cells grew more rapidly, and were highly invasive in an in vitro assay [ 22 ] . Therefore, the increased hepatic levels of junB gene, in mice treated with RU486, was expected to reflect an uncontrolled hepatocellular growth in these animals.

  • In contrast to its effect on JunB and mdm2 mRNA levels, RU 486 diminished the hepatic expression of c-myc and p53 mRNAs to comparable degrees (Fig 3).

  • Indeed, RU486 caused a remarkable 2.5-fold increase in the expression of junB mRNA (Fig 2A).


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast