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Example sentences for: junb

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The protein product of this gene is a member of the activating protein-1 (AP-1) family [ 19 ] , which upon binding to either c-fos or fos B protein form a complex that have high affinity to AP-1 binding concensus sequence [ 20 ] . A wide variety of chemicals, including growth factors, and tumor promotors increase the expression of this gene in various cell types [ 21 ] . Compared to untransfected keratinocytes, JunB-transfected cells grew more rapidly, and were highly invasive in an in vitro assay [ 22 ] . Therefore, the increased hepatic levels of junB gene, in mice treated with RU486, was expected to reflect an uncontrolled hepatocellular growth in these animals.
A remarkable 2.5-fold increase in the mRNA of JunB was detected upon treatment with RU 486 (Fig 2A).
Transcription factor genes that were modulated by IL-1β included members from the NF-κB family (relB, p100/p52, p105/p50, IκB-ε, c-rel, and p65), the AP-1 family (fra-1 and junB), and the ETS family (ets-1).
JunB was identified as an IL-1-inducible gene in chondrocytes by the Human Cancer 1.2 K array (Table 1) and this finding was confirmed by RT-PCR (Fig.
Pretreatment of mice with RU 486 caused significant increases in hepatic levels of JunB and mdm2 (Fig 2).