Words similar to junb
Example sentences for: junb
How can you use “junb” in a sentence? Here are some example sentences to help you improve your vocabulary:
This was somewhat surprising, since MAPK pathways do not activate JunB [ 29] and in some systems JunB antagonizes transcriptional activation by c-Jun [ 30].
Pretreatment of mice with RU 486 caused significant increases in hepatic levels of JunB and mdm2 (Fig 2).
The protein product of this gene is a member of the activating protein-1 (AP-1) family [ 19 ] , which upon binding to either c-fos or fos B protein form a complex that have high affinity to AP-1 binding concensus sequence [ 20 ] . A wide variety of chemicals, including growth factors, and tumor promotors increase the expression of this gene in various cell types [ 21 ] . Compared to untransfected keratinocytes, JunB-transfected cells grew more rapidly, and were highly invasive in an in vitro assay [ 22 ] . Therefore, the increased hepatic levels of junB gene, in mice treated with RU486, was expected to reflect an uncontrolled hepatocellular growth in these animals.
In contrast to its effect on JunB and mdm2 mRNA levels, RU 486 diminished the hepatic expression of c-myc and p53 mRNAs to comparable degrees (Fig 3).
Indeed, RU486 caused a remarkable 2.5-fold increase in the expression of junB mRNA (Fig 2A).