Words similar to jak
Example sentences for: jak
How can you use “jak” in a sentence? Here are some example sentences to help you improve your vocabulary:
We observed that inhibition of STAT3 activation by treatment with AG490, which inhibits JAK2 activation, resulted in apoptosis of NRP-152 but not NRP-154 cells (Table 1).
The now-activated JAK2 phosphorylates STAT3, which forms homodimers, can cross the nuclear membrane and function as a transcription factor, inducing various genes including genes involved in the cellular transformation process [ 15 ] .
Our data imply that JAK2-mediated phosphorylation of STAT3 was essential for the survival of NRP-152 cells, but that NRP-154 cells did not require activated JAK2 for survival, regardless of amount of IL-6 produced by the cell.
It has recently been suggested that G-protein coupled receptors with PDZ domains, SH2-containing domains and PTB domains participate in protein-protein interactions with partners other than G-proteins, such as Grb2 and JAK2, which may allow these receptors to bypass the G-proteins and utilize other signaling cascades (29).
Similarly to nuclear receptors and to other transcription factors, STAT proteins can interact with coactivators to modulate their transcriptional activity [ 9 10 11 12 ] . Other reports have shown direct interactions between several members of the JAK/STAT signaling pathway with SHRs [ 13 14 15 16 ] . Stat3 is one of the seven members of the STAT family of proteins that has been shown to modulate the expression of several genes related to control cell cycle, proliferation and apoptosis, such as Cyclin D1, c-myc, and Bcl-xL, respectively [ 17 ] . Accordingly, alterations in the activity of STAT3 have been associated with cell transformation and cancer progression [ 18 19 20 ] .
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