Example sentences for: jak

How can you use “jak” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cytokine receptors such as IL-3, GM-CSF, and the interferons transmit their regulatory signals primarily by the receptor-associated Jak family of tyrosine kinases, and activate STAT transcription factors.

  • Treatment with the JAK2 inhibitor for 48 hrs induced apoptosis, measured by cellular binding of FITC-annexin V, in NRP-152 but not NRP-154 clones (Table 1).

  • Our data imply that JAK2-mediated phosphorylation of STAT3 was essential for the survival of NRP-152 cells, but that NRP-154 cells did not require activated JAK2 for survival, regardless of amount of IL-6 produced by the cell.

  • Further, both the SHP-2/Ras and JAK/STAT3 pathways are activated by IL-6R/gp130 signaling (Fig.

  • The now-activated JAK2 phosphorylates STAT3, which forms homodimers, can cross the nuclear membrane and function as a transcription factor, inducing various genes including genes involved in the cellular transformation process [ 15 ] .

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