Words similar to jak
Example sentences for: jak
How can you use “jak” in a sentence? Here are some example sentences to help you improve your vocabulary:
STAT1, another signaling intermediate in the IL-6 pathway, has been observed to be activated in non-tumorigenic cells, and may function as a "check" for STAT3 phosphorylation, a possible oncogenic event [ 30 31 ] . We are investigating whether or not STAT1 is phosphorylated by JAK2 in NRP-152 cells, and whether STAT1 phosphorylation is required for the survival of NRP-152 cells.
Of particular note are c-Raf, ERK2, and JAK1.
Similarly to nuclear receptors and to other transcription factors, STAT proteins can interact with coactivators to modulate their transcriptional activity [ 9 10 11 12 ] . Other reports have shown direct interactions between several members of the JAK/STAT signaling pathway with SHRs [ 13 14 15 16 ] . Stat3 is one of the seven members of the STAT family of proteins that has been shown to modulate the expression of several genes related to control cell cycle, proliferation and apoptosis, such as Cyclin D1, c-myc, and Bcl-xL, respectively [ 17 ] . Accordingly, alterations in the activity of STAT3 have been associated with cell transformation and cancer progression [ 18 19 20 ] .
We have shown that NRP-152 and NRP-154 cells exhibit fundamental differences in the regulation of IL-6 production by dexamethasone, and in the requirement for JAK2-mediated events for survival.
In continuing our studies on the role of IL-6 in STAT3 phosphorylation, we used the JAK2 phosphorylation inhibitor AG490, to see if inhibiting JAK2 phosphorylation would inhibit survival of NRP-152 or NRP-154 cells, as had been described for LNCaP cells previously [ 29 ] . We examined clones of NRP-154, selected by amount of IL-6 expression each had: 2 high IL-6-expressing clones and 2 low-IL-6-expressing clones were used for these experiments.
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