Words similar to jak
Example sentences for: jak
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Inhibition of JAK2 induced apoptosis in NRP-152 but not NRP-154 clones
The role of the coactivators could be just as bridging factors, although some of the members of the p160 family and CBP/p300 present histone acetyltransferase activity [ 34 35 ] . Stat3 is a member of the JAK/STAT signaling pathway, which is a transcription factor itself that after activation binds to specific sequences in DNA to regulate expression of genes related to proliferation, differentiation and cell survival.
The major IL-6 signaling intermediates are JAK2 and STAT3 [ 15 ] . Homodimerization of the IL-6/receptor complex induces the autophosphorylation of JAK2.
Signaling by the IGF-IR has been studied in many different cell types and is important for proliferation, survival, motility, adhesion, transformation, tumor formation and metastasis [for reviews see refs [ 31 32 ] ]. The receptor can directly phosphorylate the insulin receptor substrate 1 (IRS-1) and Shc proteins in the intact cell causing activation of PI-3Kinase and ras signaling [ 33 ] . More recently, it has been shown that the IGF-IR signals via the Gβγ subunits of the heterotrimeric Gi complex to stimulate PI-3Kinase and ras, and also activates the JAK/Stat pathway to cause phosphorylation of Stat3 [ 34 35 ] .
IL-6 receptor binding activates JAK1 as well as JAK2, which in turn phosphorylates STAT3 [ 14 ] . This in fact has been shown to be the case for v-src-transformed fibroblasts [ 34 ] . Another hypothesis is that STAT3 activation in NRP-154 cells is not dependent upon a signaling cascade, but is constitutive, possibly due to a mutation not unlike that contained within the cSTAT3 plasmid generated by Bromberg, et al.
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