Words similar to jak
Example sentences for: jak
How can you use “jak” in a sentence? Here are some example sentences to help you improve your vocabulary:
Further experiments are underway to determine if STAT3 requires phosphorylation by a different kinase, such as JAK1, in NRP-154 cells.
Signaling by the IGF-IR has been studied in many different cell types and is important for proliferation, survival, motility, adhesion, transformation, tumor formation and metastasis [for reviews see refs [ 31 32 ] ]. The receptor can directly phosphorylate the insulin receptor substrate 1 (IRS-1) and Shc proteins in the intact cell causing activation of PI-3Kinase and ras signaling [ 33 ] . More recently, it has been shown that the IGF-IR signals via the Gβγ subunits of the heterotrimeric Gi complex to stimulate PI-3Kinase and ras, and also activates the JAK/Stat pathway to cause phosphorylation of Stat3 [ 34 35 ] .
We have shown that NRP-152 and NRP-154 cells exhibit fundamental differences in the regulation of IL-6 production by dexamethasone, and in the requirement for JAK2-mediated events for survival.
IL-6 receptor binding activates JAK1 as well as JAK2, which in turn phosphorylates STAT3 [ 14 ] . This in fact has been shown to be the case for v-src-transformed fibroblasts [ 34 ] . Another hypothesis is that STAT3 activation in NRP-154 cells is not dependent upon a signaling cascade, but is constitutive, possibly due to a mutation not unlike that contained within the cSTAT3 plasmid generated by Bromberg, et al.
Treatment with the JAK2 inhibitor for 48 hrs induced apoptosis, measured by cellular binding of FITC-annexin V, in NRP-152 but not NRP-154 clones (Table 1).
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