Words similar to jak
Example sentences for: jak
How can you use “jak” in a sentence? Here are some example sentences to help you improve your vocabulary:
The transcription factors (GATA, Friend-of-GATA, and Runx family proteins) and signal transduction pathways (Toll/NF-κB, Serrate/Notch, and JAK/STAT) that are required for specification and proliferation of blood cells during normal hematopoiesis, as well as during the hematopoietic proliferation that accompanies immune challenge, are conserved (Evans et al.
Of particular note are c-Raf, ERK2, and JAK1.
Treatment with the JAK2 inhibitor for 48 hrs induced apoptosis, measured by cellular binding of FITC-annexin V, in NRP-152 but not NRP-154 clones (Table 1).
The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.
We observed that inhibition of STAT3 activation by treatment with AG490, which inhibits JAK2 activation, resulted in apoptosis of NRP-152 but not NRP-154 cells (Table 1).
Loading...