Words similar to isoprenoid
Example sentences for: isoprenoid
How can you use “isoprenoid” in a sentence? Here are some example sentences to help you improve your vocabulary:
When they directly interfered with the isoprenoid/Rho/ROCK1 pathway by adding a drug that inhibits Rho activation, they saw effects similar to those of the statins (i.e.
Treatment of cells with a farnesyl transferase inhibitor or expression of a dominant negative (DN) ROCK1 molecule led to enhanced sAPP α shedding, supporting the notion that shedding is modulated by the isoprenoid pathway.
The theoretical link between statins and ROCK1 goes as follows: statins inhibit the isoprenoid pathway, isoprenoids are regulators of the enzyme Rho, and Rho in turn activates ROCK1.
FTI-1, an inhibitor of farnesyl transferase also known as L-744,832 [59], mimicked and potentiated statin-activated shedding, presumably by blocking transfer of isoprenoid moieties to a Rho protein by farnesyl transferase, and thereby decreasing Rho activity.
Further, we were able to demonstrate that α-secretase activity could be modulated by molecules further upstream in the isoprenoid pathway (see Figure 7).