Words similar to isoforms
Example sentences for: isoforms
How can you use “isoforms” in a sentence? Here are some example sentences to help you improve your vocabulary:
Among genes that are stimulated by FSH/cAMP during the period of maturation of Sertoli cells (15 to 20 days of age in rats), are several subunits of cAMP-dependent protein kinase (PKA), the serine/threonine kinase mainly responsible for the downstream effects of FSH [ 15 ] . Expression of the RIIβ regulatory subunit of cAMP-dependent protein kinase is highly induced (50-fold) at the mRNA level in primary cultures of rat Sertoli cells as a late response to cAMP peaking at 12 hours [ 16 ] . We have demonstrated that expression of CAAT/Enhancer binding protein β (C/EBPβ) is induced by cAMP with rapid kinetics in Sertoli cells, and that C/EBPβ is responsible for induction of late response genes like the RIIβ-gene [ 17 ] . The RIIβ promoter contains a conserved E-box/HLH element in the basal promoter localized at -280 to -275 relative to the functional ATG [ 18 ] . This element is shown to be important for cAMP-responsiveness in granulosa cells, and it has been shown to bind both USF and Myc in CHO and NB2a cells [ 18 19 ] . In this work, we show that USF isoforms may regulate cAMP responsiveness of the RIIβ promoter by modulating the effect of C/EBP, and that the formation of USF isoforms may be regulated by cAMP in Sertoli cells.
V-ATPase proteolipid isoforms were shown to exhibit differential transcript expression levels in response to environmental stresses [ 36 ] . This fact implies a possible role for these isoforms in allowing the plant to deal with stress.
Given previous work in this area, it is not unexpected that even a shift only between the fast isoforms but away from IIb would result in measurable physiological changes.
For this purpose, the urinary CTX isoforms α L, β L, and α Dwere quantified by immunoassay in healthy premenopausal and postmenopausal women, and in women affected with breast cancer either with or without bone metastases.
These kinases were examined to determine if they can act as the priming kinase for either of the 2 isoforms of GSK3, GSK3α and GSK3β.
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