Words similar to ipf

Example sentences for: ipf

How can you use “ipf” in a sentence? Here are some example sentences to help you improve your vocabulary:

We have found that fibroblasts cultured from normal and IPF human lungs have a significant and similar induction of the COX-2 enzyme when stimulated with IL-1β, but that IPF fibroblasts produced more thromboxane and had a significantly lower prostacyclin:thromboxane ratio.
Many cell types, including lung fibroblasts, contain cyclooxygenase (COX), a proximal enzyme in prostanoid production, and can generate prostanoids [ 19 ] . It has been previously reported that IPF lung fibroblasts have decreased COX-2 expression compared to normal lung fibroblasts and, hence, have decreased PGE 2 production [ 12 20 21 ] . Because of these findings and the fact that PGs are important fibroblast regulators, we sought to investigate whether abnormalities in COX-2 expression could be associated with an altered balance between profibrotic and antifibrotic PGs.
Recent reports suggesting decreased COX-2 expression and PGE 2 production in IPF fibroblasts have received significant attention [ 12 20 21 ] . In our study we found that both COX-2 protein expression and PGE 2 production were upregulated to a similar degree in IPF and normal lung fibroblasts.
We hypothesize that the lower PGI 2 :TXA 2 ratio seen in HF-IPF may be a phenotypic alteration that plays a role in the pathogenesis of IPF.
In addition, our results were similar when comparing lung fibroblasts obtained from 5 subjects with advanced stage IPF with those of 2 subjects at an earlier stage of their disease, who had received no therapy.