Words similar to ipcs
Example sentences for: ipcs
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First, our molecular analysis of differentiating IPCs showed that they remain distinct from mature pancreatic islet β-cells; in other words, the insulin + cells derived by our methods are not mature β-cells.
Immunostaining with specific antibodies revealed proinsulin and C-peptide, an internal portion of the proinsulin translation product, in the cytoplasm of all insulin + cells (see Figure 4D–4G and 4O), supporting our conclusion that insulin protein was produced in stage 4 IPCs.
1, was not detected in later stage IPCs (see Figure 1).
Thus, like in pancreatic islets, insulin was the principal hormone produced by IPCs.
Additional studies to test the impact of transplanted IPCs in animal models of diabetes therefore await production of IPCs capable of insulin secretion at levels higher than achieved here.