Example sentences for: ip

How can you use “ip” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We report that the Type III IP 3 receptor is the dominant isotype expressed in rodent taste cells and that it is primarily found in the same subset of taste cells as other known signaling components of bitter transduction.

  • IP 3 has been shown to be an important second messenger in both bitter and sweet taste transduction, and IP 3 R3 likely mediates the Ca 2+release from intracellular stores in response to IP 3 . In bitter taste transduction, many signaling components have been identified, and IP 3 R3 is co-expressed in the same taste cells (Fig.

  • Alpha gustducin activates PDE, causing decreases in intracellular cAMP, while its βγ partners stimulate PLCβ2 to produce IP 3 and DAG.

  • Two molecular loci recently have been implicated as potential modulators of GnRH receptor signaling: one is the receptor itself [ 23 ] , and the other is the G protein that transduces the signal generated by binding of the receptor to its agonist [ 9 ] . With respect to the former locus, G protein coupled receptor kinases (GRKs) act in an agonist-specific manner to phosphorylate intracellular regions of the receptor thus permitting β arrestin binding that sterically inhibits G protein association with the receptor [ 1 45 ] . We have reported previously that experimental expression of GRKs in GnRH receptor-expressing heterologous cells (COS-1) suppressed GnRH-stimulated IP 3 production, and that co-expression of GRK2 and β-arrestin 2 suppressed GnRH receptor signaling more than that of either alone [ 23 ] . Stronger evidence that the GRK/β arrestin paradigm may play a role in regulating GnRH receptor signaling is our recent finding that adenovirus-mediated gene transfer of GRK2 into normal pituitary gonadotropes suppressed GnRH-stimulated LH secretion and IP 3 production [ 31 ] . However, no evidence has been presented for a direct interaction between β-arrestin and the GnRH receptor.

  • Cytoskeletal anchored proteins were extracted, co-immunoprecipitated (IP) and analyzed (Blot) with the antibodies indicated.


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