Words similar to iono

Example sentences for: iono

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Thus, unlike the quantitative effect of U0126 on ERK activation, inhibition of MEK1 with U0126 only partially reversed the gel shift of cPLA 2 . The reversal of the gel shift was similar in cells treated with ATP and 1 and 10 μM IONO.
Treatment of MDCK cells with 30 μM PD098059, a less potent inhibitor of MEK [ 28 29 ] , resulted in a ~50% reduction in AA release in response to 100 μM ATP, 1 μM IONO, and 10 μM IONO (data not shown).
This inhibition was independent of the total amount of AA released, since AA release stimulated by 10 μM IONO was 3-fold greater than release stimulated with 1 μM IONO or 100 μM ATP, but the percent inhibition by U0126 was similar.
One explanation for the decrease in AA is that U0126 inhibits [Ca 2+] i mobilization in response to ATP or IONO, thereby preventing translocation of cPLA 2 . In chick ventricular myocytes, inhibition of MEK1/ERK by PD98059 inhibits zinterol-mediated AA release, but also inhibits zinterol-induced stimulation of [Ca 2+] i cycling in electrically stimulated cells [ 33 ] . In MDCK cells, extracellular ATP acts via P 2Y2 receptors to elicit an IP 3 -mediated [Ca 2+] i increase [ 34 ] and IONO acts to increase [Ca 2+] i by permeabilizing cell membranes to Ca 2+.
2 translocation to Golgi and ER in response 10 μM IONO (Fig.