Example sentences for: ion

How can you use “ion” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One way to do this may be to use ion channels—proteins that form a channel through which specific inorganic ions can diffuse.

  • Distinct nAChR subtypes exist that can be stimulated by the neurotransmitter acetylcholine, the natural product nicotine, or by synthetic compounds [ 1 ] . nAChR is the prototype for a protein superfamily that includes the receptors for the excitatory amino acids glutamate and aspartate, the inhibitory amino-acids gamma-aminobutyric acid (GABA) and glycine, as well as the serotonin 5-HT 3 receptor [ 1 ] . Like most ligand-gated ion channels, nAChRs are homo- or hetero-pentameric, each monomer belonging to a pull of 8 alpha- or 3 beta-subunits (alpha 2-9 , beta 2-4 ). While each subunit has four transmembrane domains, the agonist binding sites are located at the subunit interfaces [ 2 ] . Both natural and synthetic ligands can display varied affinity for different receptor subtypes.

  • Analysis of the crystal structure of GlpF suggests that potential ion binding sites may be located in the central pore, at the four-fold axis of symmetry in the tetrameric association of subunits that form the channel [ 15 ] . Interestingly, this arrangement of a tetramer of subunits to form a central ion pore is a hallmark of the family of voltage-gated ion channels [ 23 ] , which rely on a tetrameric organization to create a central pore for ions that is lined by sequences contributed from all four subunits.

  • , 1996 [ 3 ] ). For example, some classical neurotransmitters such as 5-HT have short-term effects on ion channels and other effectors such as adenylyl cyclase but also have growth factor-like effects in developing brain [ 4 ] and mitogenic effects on fibroblasts (reviewed in Gerhardt and van Heerikhuizen, 1997 [ 5 ] ). The peptide hormones insulin and IGF-1 have both short-term metabolic effects and long-term actions on cell growth and differentiation.

  • In some ligand-gated ion channels, such as ACh receptors, the agonist not only activates the receptors, but also blocks the pore as well [ 25 26 ] . In order to test if ATP blocks the P2X 2 receptors and affects open channel noise, we recorded single channel currents activated by different concentrations of ATP.


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