Words similar to intra-articular
Example sentences for: intra-articular
How can you use “intra-articular” in a sentence? Here are some example sentences to help you improve your vocabulary:
To examine the effect of TGF-β1 on joint pathology, we used adenovirus-mediated intra-articular gene delivery to confer sustained, intra-articular TGF-β1 expression in both naïve and arthritic rabbit knee joints.
Intra-articular injection of Ad.TGF-β1 virus into the rabbit knee resulted in dose-dependent elevated levels of expression of TGF-β1 in the synovial fluid, but not in the serum.
The antigen-induced arthritis model of rheumatoid arthritis in rabbits demonstrates persistent active inflammation for several months after the intra-articular injection of antigen, including hypertrophy and hyperplasia of the synovial lining cells, pannus formation with articular cartilage erosion, and chronic infiltration of synovium by lymphocytes and plasma cells [ 13 ] . In addition, Dijkstra and colleagues [ 15 ] found macrophages in the superficial layer of the synovium, where they might secrete enzymes and oxygen radicals into the joint space, which can lead to cartilage erosion [ 9 ] . The protein levels in lavage fluid from arthritic joints in this model are low enough to allow direct testing by Western blot analysis without immunoaffinity purification, as was needed with the human aspirates.
Gene transfer of TGF-β1 to the synovium is thus not suitable for treating intra-articular pathologies, such as the repair of damaged cartilage, associated with rheumatoid arthritis and osteoarthritis.
Moreover, there were no observed therapeutic or adverse effects following intra-articular injection of the low dose (1 × 10 7particles) of Ad.TGF-β1.
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