Words similar to intra-articular
Example sentences for: intra-articular
How can you use “intra-articular” in a sentence? Here are some example sentences to help you improve your vocabulary:
Previously, we and others have shown that local ex vivo and in vivo gene transfer of v-IL-10, IL-1Ra, IFN-γ, soluble IL-1 receptor, and soluble TNF receptor are able to block certain intra-articular pathologies in rabbit, rat, and murine models of arthritis.
The antigen-induced arthritis model of rheumatoid arthritis in rabbits demonstrates persistent active inflammation for several months after the intra-articular injection of antigen, including hypertrophy and hyperplasia of the synovial lining cells, pannus formation with articular cartilage erosion, and chronic infiltration of synovium by lymphocytes and plasma cells [ 13 ] . In addition, Dijkstra and colleagues [ 15 ] found macrophages in the superficial layer of the synovium, where they might secrete enzymes and oxygen radicals into the joint space, which can lead to cartilage erosion [ 9 ] . The protein levels in lavage fluid from arthritic joints in this model are low enough to allow direct testing by Western blot analysis without immunoaffinity purification, as was needed with the human aspirates.
Exclusionary laboratory values included a platelet count of > 500,000/mm 3, hematocrit <30%, and a white-blood-cell count < 3000/mm 3. Other exclusionary criteria included use of intravenous or intra-articular corticosteroids within four weeks of randomization, any prior use of cyclosporine or cyclophosphamide, use of any investigational agent within 30 days of randomization, severe extra-articular manifestations of RA, acute infection requiring antibiotic therapy within two weeks of randomization, other autoimmune disease (e.g.
Taken together, these results suggest that intra-articular expression of TGF-β1 stimulated cartilage matrix degradation while having only a minor effect on the promotion of new matrix synthesis.
However, although many genes have been effective in treating murine CIA if administrated at a time before disease onset, local intra-articular or periarticular gene transfer has not been highly effective in halting the progression of established disease.
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