Words similar to intra-articular
Example sentences for: intra-articular
How can you use “intra-articular” in a sentence? Here are some example sentences to help you improve your vocabulary:
Expression of TGF-β1 after intra-articular injection of Ad.TGF-β1
It has been speculated that intra-articular delivery of TGF-β1 would result in enhanced synthesis of new matrix [ 9 ] . Indeed, we have reported previously that the TGF-β1 gene is more effective than insulin-like growth factor type 1 and bone morphogenetic protein type 2 genes in stimulating new matrix synthesis from rabbit chondrocytes in culture.
The antigen-induced arthritis model of rheumatoid arthritis in rabbits demonstrates persistent active inflammation for several months after the intra-articular injection of antigen, including hypertrophy and hyperplasia of the synovial lining cells, pannus formation with articular cartilage erosion, and chronic infiltration of synovium by lymphocytes and plasma cells [ 13 ] . In addition, Dijkstra and colleagues [ 15 ] found macrophages in the superficial layer of the synovium, where they might secrete enzymes and oxygen radicals into the joint space, which can lead to cartilage erosion [ 9 ] . The protein levels in lavage fluid from arthritic joints in this model are low enough to allow direct testing by Western blot analysis without immunoaffinity purification, as was needed with the human aspirates.
Previously, we and others have shown that local ex vivo and in vivo gene transfer of v-IL-10, IL-1Ra, IFN-γ, soluble IL-1 receptor, and soluble TNF receptor are able to block certain intra-articular pathologies in rabbit, rat, and murine models of arthritis.
In particular, local intra-articular expression in naïve joints stimulated cartilage breakdown, as measured by synovial GAG levels, without enhancing new matrix synthesis.
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