Words similar to intra-articular
Example sentences for: intra-articular
How can you use “intra-articular” in a sentence? Here are some example sentences to help you improve your vocabulary:
Previously, we and others have shown that local ex vivo and in vivo gene transfer of v-IL-10, IL-1Ra, IFN-γ, soluble IL-1 receptor, and soluble TNF receptor are able to block certain intra-articular pathologies in rabbit, rat, and murine models of arthritis.
The antigen-induced arthritis model of rheumatoid arthritis in rabbits demonstrates persistent active inflammation for several months after the intra-articular injection of antigen, including hypertrophy and hyperplasia of the synovial lining cells, pannus formation with articular cartilage erosion, and chronic infiltration of synovium by lymphocytes and plasma cells [ 13 ] . In addition, Dijkstra and colleagues [ 15 ] found macrophages in the superficial layer of the synovium, where they might secrete enzymes and oxygen radicals into the joint space, which can lead to cartilage erosion [ 9 ] . The protein levels in lavage fluid from arthritic joints in this model are low enough to allow direct testing by Western blot analysis without immunoaffinity purification, as was needed with the human aspirates.
The use of intravenous or intra-articular corticosteroids was not permitted.
Three weeks later, animals with positive skin tests to ovalbumin received intra-articular injections of 1 mg of sterile ovalbumin into one knee and an equal volume of sterile saline in the contralateral control knee weekly for 3 weeks.
Use of the synovium as a target tissue for TGF-β1 gene transfer, resulting in elevating the intra-articular level, is thus not appropriate for the enhancement of repair of cartilage defects.
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