Words similar to interferon
Example sentences for: interferon
How can you use “interferon” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, recent reports indicate that transcription of the p27 Kip1gene can be activated by neuronal differentiation [ 12 ] , treatment with vitamin D3 [ 13 14 ] , interferon and cytokines [ 15 16 17 ] , and exposure to hypoxic conditions [ 18 ] or xenobiotics [ 19 ] . Transcription of the p27 Kip1gene can be negatively regulated by growth factors [ 20 ] and by c-Myc [ 21 ] . Some of the growth factor and cytokine effects on p27 Kip1transcription may be mediated by the forkhead family of transcription factors that appear to be regulated downstream of the phosphatidylinositol 3-kinase signaling pathway [ 22 23 24 25 ] . The use of alternative promoters leading to multiple transcription start sites, as reported here, suggests an additional type of transcriptional control.
Preliminary data suggest that the combination of pegylated interferon and ribavirin will increase sustained response rates to more than 50% overall, and to greater than 40% in patients with hepatitis C genotype 1 infection [ 18 ] . Hepatologists need to understand other physicians' perspectives on hepatitis C so that they can adequately address their concerns about treatment issues.
As mentioned before, cytoplasmic dsRNA can trigger a series of signaling reactions that lead to interferon (IFN) synthesis [ 5 6 ] . In the "interferon response", dsRNA molecules activate protein kinase PKR and 2',5'-oligonucleotide synthetase.
Several groups of genes involved in different aspects of the immune response to an infection were uncovered by literature profiling (interferon response, chemotaxis, inflammation: Figure 6d,6f, and 6g, respectively).
(iii) Lack of interferon response: We provide direct experimental evidence that the 21-nt dsRNA does not trigger an IFN response, which is an advantage because an IFN response would have caused a general and non-specific inhibition of all cap-dependent translation [ 5 ] . (iv) Regulation any time: Although we have not tested this specifically, one can, in principle, transfect the virus-infected cell with dsRNA at any time point during infection.
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