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Example sentences for: initial
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Antigen-specific T cells encounter antigen presented by dendritic cells that migrate to the paracortical regions of draining lymph nodes after initial antigen contact [ 1 ] . Only dendritic cells have the capacity to induce activation in resting peripheral T cells [ 2 3 ] . Once activated, differentiated T helper cells contact antigen-specific B cells and provide signals for B cell differentiation via CD154-CD40 interactions, as well as by the production of cytokines [ 4 5 6 ] . Consistent with this general understanding of the induction of antibody responses to protein immunogens, good antibody responses to synthetic peptide-epitope constructs have been shown to depend on the presence, orientation, and multiplicity of the T cell epitope in the construct [ 7 8 9 10 11 ] . As a confirmation of this finding with synthetic epitope constructs, most protein immunogens studied to date contain multiple T cell epitopes, for example [ 12 13 ] .
The death toll from the initial 7.6-magnitude quake has topped 2,000 and is expected to rise as rescuers search for 2,300 people believed to be trapped in the rubble.
Via the endosomal compartment, PEI/DNA complexes travel to the nucleus, whereupon the plasmid DNA is expressed within 5 hours after the initial attachment of the complexes to the cell surface [ 7].
In these already overpopulated islands, where Roman Catholicism is the predominant religion, the government provides an initial lump sum for each birth and a monthly support grant, allocation familiale, for each child.
Steady-state parameters of K m and k cat were calculated from initial rates using a series of substrate concentrations over a 15-fold range below and above K m . Protein concentrations were estimated by the Bradford assay [ 41] with bovine serum albumin as the protein standard.
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