Example sentences for: infectivity

How can you use “infectivity” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Several laboratory studies have been conducted in which aerosolized respiratory viruses have been collected and quantified with culture based methods [ 11 12 13 ] . These studies were conducted to determine the effects of temperature and relative humidity on the infectivity of respiratory viruses, but their methods are not suitable for the extremely low concentrations of virus in field experiments.

  • The unbound viral particle fraction, collected after each addition cycle, was subjected to infectivity analysis on D-17 cells to estimate the number of unbound Ad5.CMV-LacZ.

  • Cellulose acetate phthalate (CAP) is a promising microbicide candidate for prevention of infection by sexually transmitted disease (STD) pathogens, including HIV-1 [ 1 2 3 4 5 6 7 ] . CAP inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120, while leaving the site for the primary cellular receptor CD4 accessible [ 8 9 ] Soluble CD4 (sCD4) was shown to inhibit HIV-1 infection by two mechanisms: reversible blockage of virus binding to receptors, and irreversible inactivation of virus infectivity [ 10 ] . Since CAP and sCD4 bind to distinct domains on the HIV-1 envelope, it was of interest to determine whether or not these two ligands affect virus infectivity synergistically as do other combinations of anti-HIV-1 drugs and sCD4 [ 11 12 ] Binding of sCD4 leads to conformational changes in gp120 [ 13 14 15 16 17 ] . Binding of gp120 to coreceptors CXCR4 and CCR5, respectively, triggers additional conformational changes in HIV-1 envelope glycoproteins [ 18 19 ] For these reasons it was of interest to determine whether a) pretreatment of HIV-1 with sCD4 would affect subsequent binding of CAP to virus particles, and b) CAP binding to virus particles in the presence or absence of sCD4 would elicit conformational changes which could affect HIV-1 infectivity.

  • This may be one possible explanation of why infectivity enhancement was seen with adenovirus-microbead conjugates and was not with adenoviral vectors immobilized on streptavidin-coated wells, except for one cell line (C6).

  • Lentiviruses like HIV possess a gene that encodes an protein called Vif (‘viral infectivity factor’) that counters APOBEC3G (Sheehy et al.


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