Words similar to importance
Example sentences for: importance
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The involvement of Rho GTPases in regulating integrin dependent events such as leukocyte homotypic aggregation and in chemokine upregulation of integrin-mediated adhesion has recently been identified [ 18 19 ] . ADP-ribosylation of Rho in neutrophils by treatment with C3 not only inhibits cellular locomotion, but augments chemoattractant induced actin polymerization [ 20 21 ] . Moreover, inactivation of Rho in monocytic cells leads to accelerated formation of filopodia, and it has been proposed that Rho is a negative regulator of actin polymerization within this cell type [ 22 ] . Active Rho is also required for normal morphology, motility, and cytolytic activity of IL-2 activated NK cells [ 23 24 ] . We and others have demonstrated the importance of Rho in T lymphocyte activation [ 25 26 ] . Given the role played by Rho in the regulation of actin microfilaments in other cell types, and the indispensability of a functional actin cytoskeleton in lymphocyte motility and activation, it is of importance to study Rho's role in the regulation of T lymphocyte integrin function and maintenance of cytoskeletal organization.
Bone is the most common target site of metastatic invasion in breast cancer [ 1 ] . This is of clinical importance as metastatic bone disease is associated with increased morbidity and excess mortality [ 2 ] . To initiate successful preventive therapy it is thus imperative that the bone metastases are detected early [ 3 ] .
For starters, Hoodlum elevates Johnson's importance at the expense of Stephanie St. Clair, a k a Madame Queen (Cicely Tyson), an immigrant from Martinique who became a numbers millionaire, and for whom Johnson went to work after his release from jail.
Whereas it is easy to explain this by referring to the cultural importance of food in African societies, the same reasoning can hardly be applied to the case of English, which has its own fair share of food images.
The importance of modeling multiple risk factors for various diseases has also been emphasized in recent studies [ 32 ] .
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