Words similar to importantly
Example sentences for: importantly
How can you use “importantly” in a sentence? Here are some example sentences to help you improve your vocabulary:
Importantly, several of these genes - those for eotaxin [ 20], VCAM-1 [ 21], MCP-1 [ 22] and MCP-3 [ 20] - were previously known to be inducible by IL-4 in cells relevant to pulmonary inflammation, and this regulation is corroborated here in vivo in the pulmonary tissue of a non-human primate.
This cell line spontaneously differentiates in culture and expresses biochemical and morphological characteristics of well-differentiated small intestine-like enterocytes [ 17 23 ] . We have previously shown that Caco-2 cells possess a classical nuclear vitamin D receptor [ 18 ] that directly mediates vitamin D-dependent gene expression [ 22 ] , and exhibits a high degree of specificity for various vitamin D metabolites and analogs [ 20 21 ] . Most importantly, in response to short-term (<24 h) 1,25-dihydroxyvitamin D treatment, Caco-2 cells increase transepithelial calcium transport [ 17 ] and calbindin D 9K expression [ 19 ] , a cytosolic calcium binding protein.
The angiogenic response in skeletal muscle is thought to be mediated by a number of angiogenic factors including, most importantly, vascular endothelial growth factor (VEGF).
More importantly, LSNY has to hold onto its federal funding.
[ 11 12 13 14 ] . Kidney transplants between normal and transgenic Tg26 siblings suggested that specific HIV-1 proteins within the kidney, and not circulating factors, transform infected renal epithelium [ 13 ] . Indeed, HIV-1 transgenic mice generated with an HIV-1 proviral construct mutated in the Nef "PXXP" SH3-binding motif for Src-family kinases failed to develop nephropathy [ 31 ] , and a recent in vitro analysis of podocytes infected with single gene mutants of HIV-1 further suggest that Nef plays a central role in causing the proliferative phenotype in HIVAN [ 8 ] . Utilizing these same single gene mutant viruses, we showed here that Nef appears to be play a role in the up-regulation of cyclin D 1 by HIV-1 in vitro . Importantly, these single gene mutants do not exclude the possibility that other HIV-1 gene(s) may cooperate with nef to induce cyclin D1, particularly
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