Words similar to immunosuppression
Example sentences for: immunosuppression
How can you use “immunosuppression” in a sentence? Here are some example sentences to help you improve your vocabulary:
The Tat protein has been shown to transcriptionally repress host cellular genes and be involved in the immunosuppression associated with viral infection.
Due to this, interpretation of colonic biopsies for intestinal A-GVHD may be a major diagnostic challenge especially for those not conversant with these findings [ 10 ] . Only a few studies have statistically evaluated the diagnostic significance of some histopathological features [ 6 ] . A-GVHD is treated with immunosuppression which may worsen an underlying infective condition.
COX-2 is an inducible enzyme upregulated in inflammatory states [ 20 21 ] . Notably, many NSCLC and what have been characterized as "premalignant" lung lesions have been shown to constitutively express the COX-2 enzyme and produce prostaglandin E-2 (PGE-2), the primary product of the COX-2 pathway [ 22 23 24 25 26 ] . Importantly, PGE-2 production by tumor cells has been linked to tumor-induced immunosuppression in NSCLC [ 2 3 4 5 ] . PGE-2 has been shown to directly suppress T cell mediated immunity, the primary effector against tumor cells, at a variety of levels [ 2 3 4 5 6 7 ] . Further, PGE-2 has been shown to induce the IL10 in mononuclear cells [ 4 5 ] . IL10 is a prominent immunosuppressive cytokine that may have a dominant role in preventing innate antitumor responses in the NSCLC environment [ 2 3 4 5 ] , [ 8 9 10 11 12 13 14 15 16 17 18 19 ] . Among myriad suppressive effects on T cells and antigen presenting cells, IL10 is known to inhibit IL12 production [ 14 15 16 17 18 ] . IL12 plays a key role in the initiation and potentiation of cellular immune responses and alteration of the IL12 producing function in circulating mononuclear phagocytes may be a critical factor in suppressed T cell immunity to NSCLC [ 27 28 ] .
New drug regimens capable of inducing tolerance to the transplanted islets would allow recipients to maintain their grafts without general immunosuppression and its associated toxicities.
In cases of marked immunosuppression, either in advanced AIDS or other forms of depressed cellular immunity, the management of coccidioidomycosis is particularly challenging and requires aggressive treatment [26].
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