Words similar to immunosuppression
Example sentences for: immunosuppression
How can you use “immunosuppression” in a sentence? Here are some example sentences to help you improve your vocabulary:
Current study supports our hypothesis that the immunosuppression results in an increased expression of cyclin inhibitor p21, which by inhibiting the expression of cyclins controls the allo-immune activation.
Latent CMV in many organs can be reactivated from its dormant state by several means of immunosuppression, including transmission from donors to immunosuppressed recipients of transplants, and blood transfusion.
HIV-infected individuals are highly susceptible to contracting tuberculous infection and are prone to rapid evolution of active disease [ 10 ] . The rate of tuberculosis is high in African Americans and in injection drug users [ 11 ] . Although the prevalence of a positive AFB smear in patients with pulmonary MTB is approximately the same in HIV-infected and noninfected individuals, it may decline in advanced HIV-mediated immunosuppression [ 12 ] . A previous study of 133 HIV-infected adults with pulmonary MTB showed 14% of them had a normal chest radiograph [ 13 ] .
The pulmonary complications are also likely to vary according to geographic locations, HIV risk factor, and severity of immunosuppression.
COX-2 is an inducible enzyme upregulated in inflammatory states [ 20 21 ] . Notably, many NSCLC and what have been characterized as "premalignant" lung lesions have been shown to constitutively express the COX-2 enzyme and produce prostaglandin E-2 (PGE-2), the primary product of the COX-2 pathway [ 22 23 24 25 26 ] . Importantly, PGE-2 production by tumor cells has been linked to tumor-induced immunosuppression in NSCLC [ 2 3 4 5 ] . PGE-2 has been shown to directly suppress T cell mediated immunity, the primary effector against tumor cells, at a variety of levels [ 2 3 4 5 6 7 ] . Further, PGE-2 has been shown to induce the IL10 in mononuclear cells [ 4 5 ] . IL10 is a prominent immunosuppressive cytokine that may have a dominant role in preventing innate antitumor responses in the NSCLC environment [ 2 3 4 5 ] , [ 8 9 10 11 12 13 14 15 16 17 18 19 ] . Among myriad suppressive effects on T cells and antigen presenting cells, IL10 is known to inhibit IL12 production [ 14 15 16 17 18 ] . IL12 plays a key role in the initiation and potentiation of cellular immune responses and alteration of the IL12 producing function in circulating mononuclear phagocytes may be a critical factor in suppressed T cell immunity to NSCLC [ 27 28 ] .
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