Words similar to immunosuppressive
Example sentences for: immunosuppressive
How can you use “immunosuppressive” in a sentence? Here are some example sentences to help you improve your vocabulary:
Maintenance immunosuppressive medication use at the time of discharge after transplantation was also analyzed as a preexisting covariate.
One mechanism by which tumors evade immune destruction is through cytokine production or induction [ 1 ] . Prostaglandin E-2 (PGE-2), constitutively produced by many NSCLC has been identified as one factor that has direct immunosuppressive properties and is known to induce IL10 in mononuclear cells [ 2 3 4 5 6 7 ] . IL10 is a dominant immunosuppressive cytokine found in the NSCLC environment known to directly affect T cell-mediated immunity [ 2 3 4 5 6 7 8 9 10 11 12 ] . Both PGE-2 and IL10 have been shown to suppress antigen presentation, to suppress cytotoxic T cell (CTL) responses, and to inhibit cytokine production by T cells and antigen presenting cells, perhaps most importantly IL12, that plays a central role in initiation and potentiation of cellular immune responses [ 2 3 4 5 6 7 ] , [ 11 12 13 14 15 16 17 18 19 ] . We asked whether PGE-2 levels and/or IL10 levels were elevated in plasma of NSCLC patients, whether monocytes from NSCLC patients produce more IL10 than normals, and whether there was correlation within our findings.
However, the findings of the present analysis suggest a need for providers nationally to reevaluate the use of immunosuppressive agents in a systematic fashion after transplantation.
The current study almost certainly underestimates the incidence of serious immunosuppressive drug toxicity in this population.
For example, tamoxifen resistance in a xenograft model of advanced human breast cancer, was recently shown [ 50] to be associated with an increase in TGF-βs and concomitant immunosuppressive effects on natural killer cells.
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