Example sentences for: immunosuppressive

How can you use “immunosuppressive” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The addition of SRL to the immunosuppressive regimen of Tac resulted in decreased lymphocyte proliferation exhibiting decreased allo-immune response.

  • A number of studies have demonstrated that long treatment of both CsA and TAC is associated many side effects such as nephrotoxicity, hypertension, and gingival hyperplasia [ 1 2 ] . Rapamycin clinically termed, as Sirolimus (SRL) is a new immunosuppressive agent, which is structurally similar to TAC, binds to same binding protein FKBP, but has different mechanism of action [ 3 ] . Both clinical and experimental studies demonstrated that SRL when used either with CsA or alone is associated with side effects like hyperlipidemia, thrombocytopenia and nephrotoxicity [ 4 5 6 7 ] . SRL and TAC compete for the same binding site and hence it was thought they could not be used concomitantly.

  • Thirty intervals of care were excluded from the analysis because they occurred in subgroups with very small numbers of patients, within which it would have been impossible to obtain stable disease-specific estimates (HIV (4 men; 2 women); chronic renal disease (5 men; 7 women) and immunosuppressive therapy (3 men; 10 women)).

  • CMV is the most important pathogen among these patients and the virus can cause both direct and indirect effects [ 8 9 10 11 12 13 ] . Among solid organ transplant recipients, the effects of CMV disease are similar among all patients, with the exception being the effect on the transplanted organ [ 10 14 15 16 17 ] . The most common disease presentation of CMV in AIDS patients is retinitis [ 8 11 ] . The significance of CMV disease in transplant and HIV infected individuals goes much further than the direct pathological effects because CMV has been shown to be an immune modulator and may contribute significantly to the net immunosuppressive status of the patient [ 11 ] . This immunomodulation would therefore increase the susceptibility to superinfections from other pathogens.

  • The long-term treatment of patients with either CsA or TAC results in side effects such as nephrotoxicity, hypertension, and gingival hyperplasia [ 1 2 ] . Sirolimus (SRL) a new immunosuppressive agent is structurally similar to TAC binds to same binding protein FKBP, but its mechanism of action is different [ 3 ] . Both clinical and experimental studies demonstrated that SRL when used either with CsA or alone is associated with side effects such as hyperlipidemia, thrombocytopenia and nephrotoxicity [ 4 5 6 7 ] . Since SRL and TAC have affinity for the same binding site, it was thought to be ineffective when used together.


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