Words similar to immunosuppressive
Example sentences for: immunosuppressive
How can you use “immunosuppressive” in a sentence? Here are some example sentences to help you improve your vocabulary:
Information on use of medications (other than immunosuppressive medications), alcohol, tobacco, or radiologic procedures was not available.
We characterized each influenza/ILI episode according to: (1) age at time of influenza/ILI diagnosis; (2) gender; (3) recorded influenza immunization status; (4) prior influenza/ILI episodes during the study period; (5) antiviral influenza treatment (amantadine or rimantadine); (6) total patient health care costs in the three months before influenza/ILI diagnosis); (7) co-morbidities for which health services were received in (a) the 30 days and (b) the year before influenza/ILI diagnosis (chronic lung disease, chronic renal disease, diabetes, malignancies, HIV infections, and chronic heart disease); (8) immunosuppressive and chronic corticosteroid drug use during the year before influenza/ILI diagnosis; (9) health services in the 30 days before influenza/ILI diagnosis for conditions that would have been characterized as complications or manifestations had they occurred during the influenza/ILI episode (see below).
For example, tamoxifen resistance in a xenograft model of advanced human breast cancer, was recently shown [ 50] to be associated with an increase in TGF-βs and concomitant immunosuppressive effects on natural killer cells.
Thus, while some patients with a pancreas transplant tolerate the immunosuppressive agents well, and for such patients diabetic nephropathy can gradually improve, in other patients the net effect (decreased risk due to the improved blood glucose control, increased risk from the immunosuppressive agents) may worsen kidney function.
The selective suppression of Th1 cell activity is believed to be due to IL-10 inhibition of IL-12, a differentiation factor for Th1 cells [ 11 12 ] . The release of reactive oxygen and nitrogen intermediates by macrophages is also suppressed by IL-10 [ 13 14 ] . In addition, IL-10 stimulates the production of cytokine inhibitors such as IL-1 receptor antagonist [ 15 ] . In patients with rheumatoid arthritis, IL-10 is produced by synovial membrane cells and is found at high levels in the synovial fluid [ 16 17 ] . It has been shown that suppression of IL-10 production by synovial cells is associated with increased levels of IL-1 and TNF-α, suggesting that IL-10 plays a suppressive role in rheumatoid arthritis joints [ 16 ] . It was also observed that IL-10 directly stimulated proteoglycan synthesis and reversed the cartilage degradation induced by activated mononuclear cells [ 18 ] . These immunosuppressive activities indicate that IL-10 is a potential therapeutic approach for autoimmune diseases.
Loading...