Example sentences for: immunosuppressive

How can you use “immunosuppressive” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For example, tamoxifen resistance in a xenograft model of advanced human breast cancer, was recently shown [ 50] to be associated with an increase in TGF-βs and concomitant immunosuppressive effects on natural killer cells.

  • Maintenance immunosuppressive medication use at the time of discharge after transplantation was also analyzed as a preexisting covariate.

  • The selective suppression of Th1 cell activity is believed to be due to IL-10 inhibition of IL-12, a differentiation factor for Th1 cells [ 11 12 ] . The release of reactive oxygen and nitrogen intermediates by macrophages is also suppressed by IL-10 [ 13 14 ] . In addition, IL-10 stimulates the production of cytokine inhibitors such as IL-1 receptor antagonist [ 15 ] . In patients with rheumatoid arthritis, IL-10 is produced by synovial membrane cells and is found at high levels in the synovial fluid [ 16 17 ] . It has been shown that suppression of IL-10 production by synovial cells is associated with increased levels of IL-1 and TNF-α, suggesting that IL-10 plays a suppressive role in rheumatoid arthritis joints [ 16 ] . It was also observed that IL-10 directly stimulated proteoglycan synthesis and reversed the cartilage degradation induced by activated mononuclear cells [ 18 ] . These immunosuppressive activities indicate that IL-10 is a potential therapeutic approach for autoimmune diseases.

  • Information on use of medications (other than immunosuppressive medications), alcohol, tobacco, or radiologic procedures was not available.

  • Among renal transplant recipients with diabetes, the most common cause of hospitalized poisonings was insulin/antidiabetic agents, while in patients who experienced allograft rejection, the most common cause of hospitalized poisonings was immunosuppressive agents.


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