Example sentences for: immunosuppressive

How can you use “immunosuppressive” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cryptosporidiosis is caused by a coccidian parasite, Cryptosporidium , which is transmitted in its infective form, the oocyst, by the fecal-oral route [ 1 ] . It causes self-limited, watery diarrhea in immunocompetent individuals but can be severe and life threatening in people with immunosuppressive conditions [ 2 ] . Because of the severe nature of the disease in the immunocompromised, most epidemiologic studies have focussed on people with HIV/AIDS and other immunosuppressed states [ 3 4 5 6 7 8 9 ] . What is known about transmission patterns in the general US population is based on studies undertaken during outbreaks of the disease, usually waterborne [ 10 11 12 13 14 15 16 ] . Even though cryptosporidiosis is a reportable disease, limited data are available on the routes of endemic transmission and on accurate incidence rates of cryptosporidiosis, especially in the immunocompetent population.

  • Improvements in isolation techniques and immunosuppressive regimens ushered in the first human islet transplantation clinical trails in the mid-1980s.

  • One mechanism by which tumors evade immune destruction is through cytokine production or induction [ 1 ] . Prostaglandin E-2 (PGE-2), constitutively produced by many NSCLC has been identified as one factor that has direct immunosuppressive properties and is known to induce IL10 in mononuclear cells [ 2 3 4 5 6 7 ] . IL10 is a dominant immunosuppressive cytokine found in the NSCLC environment known to directly affect T cell-mediated immunity [ 2 3 4 5 6 7 8 9 10 11 12 ] . Both PGE-2 and IL10 have been shown to suppress antigen presentation, to suppress cytotoxic T cell (CTL) responses, and to inhibit cytokine production by T cells and antigen presenting cells, perhaps most importantly IL12, that plays a central role in initiation and potentiation of cellular immune responses [ 2 3 4 5 6 7 ] , [ 11 12 13 14 15 16 17 18 19 ] . We asked whether PGE-2 levels and/or IL10 levels were elevated in plasma of NSCLC patients, whether monocytes from NSCLC patients produce more IL10 than normals, and whether there was correlation within our findings.

  • Maintenance immunosuppressive medication use at the time of discharge after transplantation was also analyzed as a preexisting covariate.

  • Information on use of medications (other than immunosuppressive medications), alcohol, tobacco, or radiologic procedures was not available.

How many words do you know? Try our free vocabulary size test!


Search for example sentences

Loading Loading...