Example sentences for: immunosuppressive

How can you use “immunosuppressive” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cryptosporidiosis is caused by a coccidian parasite, Cryptosporidium , which is transmitted in its infective form, the oocyst, by the fecal-oral route [ 1 ] . It causes self-limited, watery diarrhea in immunocompetent individuals but can be severe and life threatening in people with immunosuppressive conditions [ 2 ] . Because of the severe nature of the disease in the immunocompromised, most epidemiologic studies have focussed on people with HIV/AIDS and other immunosuppressed states [ 3 4 5 6 7 8 9 ] . What is known about transmission patterns in the general US population is based on studies undertaken during outbreaks of the disease, usually waterborne [ 10 11 12 13 14 15 16 ] . Even though cryptosporidiosis is a reportable disease, limited data are available on the routes of endemic transmission and on accurate incidence rates of cryptosporidiosis, especially in the immunocompetent population.

  • Improvements in isolation techniques and immunosuppressive regimens ushered in the first human islet transplantation clinical trails in the mid-1980s.

  • One mechanism by which tumors evade immune destruction is through cytokine production or induction [ 1 ] . Prostaglandin E-2 (PGE-2), constitutively produced by many NSCLC has been identified as one factor that has direct immunosuppressive properties and is known to induce IL10 in mononuclear cells [ 2 3 4 5 6 7 ] . IL10 is a dominant immunosuppressive cytokine found in the NSCLC environment known to directly affect T cell-mediated immunity [ 2 3 4 5 6 7 8 9 10 11 12 ] . Both PGE-2 and IL10 have been shown to suppress antigen presentation, to suppress cytotoxic T cell (CTL) responses, and to inhibit cytokine production by T cells and antigen presenting cells, perhaps most importantly IL12, that plays a central role in initiation and potentiation of cellular immune responses [ 2 3 4 5 6 7 ] , [ 11 12 13 14 15 16 17 18 19 ] . We asked whether PGE-2 levels and/or IL10 levels were elevated in plasma of NSCLC patients, whether monocytes from NSCLC patients produce more IL10 than normals, and whether there was correlation within our findings.

  • Maintenance immunosuppressive medication use at the time of discharge after transplantation was also analyzed as a preexisting covariate.

  • Information on use of medications (other than immunosuppressive medications), alcohol, tobacco, or radiologic procedures was not available.


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