Words similar to immunosuppressive
Example sentences for: immunosuppressive
How can you use “immunosuppressive” in a sentence? Here are some example sentences to help you improve your vocabulary:
We were unable to evaluate the effect of HIV infection, chronic renal disease, and immunosuppressive therapy due to small number of patients with these co-morbidities.
In some circumstances, CD4 +and CD8 +T cells were rendered inactive in tumor-bearing hosts [ 8 ] . The inactivation of CD4 +T cells has been attributed either to the tumor cells themselves or to bone marrow-derived cells [ 9 10 11 ] , whereas antigen ignorance or loss of memory have been postulated to underlay that of CD8 +T cells [ 12 13 ] . Other studies have suggested that tumor cells can secrete immunosuppressive factors such as TGF-β or express Fas ligand to induce apoptosis of infiltrating lymphocytes [ 14 15 16 ] . Furthermore, the tumor vasculature appears to be quite different from normal blood vessels, in terms of structural organization, interstitial pressure, and flow patterns [ 17 ] , and in reduced lymphocyte and natural killer cell homing and adhesion [ 18 19 20 21 ] . The existence of significant barriers to effective immunological destruction is further illustrated by a mouse model of concurrent multistage tumorigenesis and anti-oncogene autoimmunity, wherein progenitor dysplastic lesions are infiltrated and disrupted, while solid tumors are not [ 22 ] . The hypothesis is that the microenvironment of certain types of solid tumor can serve to locally suppress T cell infiltration.
We have earlier demonstrated that TGF-β in part mediates the immunosuppressive effects of these drugs [ 11 12 21 22 ] and therefore the increased levels of TGF-β may partially explain the increased inhibition of mitogen induced lymphocyte proliferation.
The independent associations between patient factors and hospitalizations for poisonings were examined using multivariate analysis with stepwise Cox Regression (likelihood ratio method) including recipient and donor age, recipient race, gender, weight, pretransplant dialysis (yes/no), year of transplant, duration of dialysis prior to transplantation, total follow-up time, repeat transplant, donor cytomegalovirus serology, dialysis in the first week after transplant (delayed graft function, yes/no), rejection (diagnosis or treatment) occurring during the first six months after transplant, induction antibody therapy, maintenance immunosuppressive medications at time of discharge after transplant surgery, graft loss (analyzed as a time-dependent covariate as previously described), [ 9 ] and cause of ESRD (diabetes, systemic lupus erythematosus (because of the potential effect of corticosteroid therapy prior to renal transplantation), hypertension and glomerulonephritis).
Anti-neoplastic/immunosuppressive agents were the most common cause of poisonings in this population, as would be expected.
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