Words similar to immunomodulatory
Example sentences for: immunomodulatory
How can you use “immunomodulatory” in a sentence? Here are some example sentences to help you improve your vocabulary:
These include using various adjuvants, such as incomplete Freund's adjuvant and immunomodulatory agents, such as IL-12 [4], GM-CSF [5], anti-CTLA-4 Abs [35], or heat shock proteins [36].
DEK is a nuclear protein that is not structurally related to any known family of proteins [ 12 13 ] . Although it may also participate in DNA replication and RNA processing [ 14 15 ] , we have identified DEK as a DNA-binding protein that recognizes the TG-rich peri- ets (pets) regulatory element in the human immunodeficiency virus type 2 (HIV-2) enhancer [ 16 ] . The pets site is important in mediating HIV-2 enhancer stimulation in activated T cells and monocytes [ 17 18 19 ] , suggesting that DEK may play an immunomodulatory role as it participates in transcriptional activation through this and related sites.
Some promising results have been obtained using immunomodulatory drugs, including cyclosporine [60] and hydroxyurea [61], in combination with antiviral therapy, presumably because of the limitation of T cell activation.
We advocate that such immunomodulatory approaches be tested first in controlled models where the results can be appropriately attributed to the agent itself.
The drugs have been studied with relation to their effect in Graves' hyperthyroidism which, like psoriasis, is an autoimmune disorder [ 9 10 11 12 ] Antithyroid thioureylenes, of which propylthiouracil, methimazole and carbimazole are used in clinical practice, have known immunomodulatory properties [ 13 14 ] and, in the case of psoriasis, also have antiproliferative effects as demonstrated by their ability to produce a decline in markers of cellular proliferation such as proliferative cell nuclear antigen (PCNA) [ 15 ] .
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