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Example sentences for: ici

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Estrogen receptor antagonist, ICI 182,780 completely, and tamoxifen partially reversed the neuroprotective effects of 17β-estradiol using cell death as an end point.
ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
When a visitor to one of the councils asked, “Qui est-ce qui parle francais ici?”
Moreover, these interactions were suppressed by SERMs (ICI, raloxifene and tamoxifen).
Interestingly, however, ICI 182,780, a prototypic estrogen antagonist, blocked the protective effect of 17β-estradiol on neuronal cell death (P < 0.05) while tamoxifen had only a partial effect that was not significant (Figure 8D).