Words similar to ici
Example sentences for: ici
How can you use “ici” in a sentence? Here are some example sentences to help you improve your vocabulary:
“Ici, en France, n'importe qui a le droit de jumbo frank-furter . Mais on n'a pas le droit d'apprendre aux enfants que, l'époque de Rabelais, les gens auraient jumbo frankfurter . Pas de question, Pepe.”
ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
To determine the mechanism of estrogen protection, the cultures were incubated with either ICI 182,780 (100 nM) (Tocris) or tamoxifen (10 nM) (Sigma).
ICI 182,780 was a gift from Alan Wakeling (Astra/Zeneca Pharmaceuticals, Macclesfield UK).
Both ICI 182,780 and tamoxifen alone did not produce neurotoxicity at the above concentrations (Figure 8D).