Words similar to ibd

Example sentences for: ibd

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MAdCAM-1 is expressed basally in these tissues and is dramatically increased in inflammatory bowel disease (IBD).
With respect to inflammatory bowel disease, MAdCAM-1 appears to be essential to the lymphocyte homing to the mucosa associated lymphoid tissue (MALT) [ 6 37 38 46 ] . Since MAdCAM-1 is normally expressed mainly within the gut microvasculature, and is dramatically amplified during IBD, it has been suggested that increased MAdCAM-1 expression contributes to the etiology of IBD through its ability to direct homing of lymphocytes to the gut.
Our findings suggest that lymphatic or gut endothelial transfection with Th2 cytokines like IL-10 may be an effective method to reduce important clinical symptoms associated with IBD which are mediated by MAdCAM-1 dependent lymphocyte adhesion.
Previous positional cloning studies have revealed three genes associated with IBD that carry variants with a causative role.
This may reflect the fact that TNF-α therapies for IBD are aimed at efficiently clearing TNF-α, while IL-10 therapies must increase IL-10 and recombinant IL-10 is likely too rapidly cleared from the circulation after in vivo administration to provide a uniform protection [ 55 ] . On the other hand, IL-10 gene transfer technology has been used with some success in models of colitis, however its effectiveness is also variable.