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Example sentences for: ibat

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In hamsters, rats and mice, increases and decreases in bile acid absorption at the brush border membrane are mediated by an up- or down-regulation in IBAT gene transcription [ 33 34 ] . In several rodent species including mice, regulation of IBAT is clearly dependent on intraluminal bile acid concentrations and occurs via a negative feedback mechanism [ 33 34 35 ] . Feeding of bile acids suppresses transcription of IBAT mRNA and reduces IBAT protein abundance; feeding of the bile acid binder cholestyramine has the opposite effect.
In summary, in the widely studied cftr knockout mouse model (which clearly demonstrates intestinal pathology), the apical sodium dependent ileal bile acid transporter is expressed and functions at higher levels than in wild-type animals, with intermediate levels of IBAT expression and function in heterozygous cftr (+/-) mice.
Polyclonal rabbit antibodies were obtained from a commercial source (Research Genetics, Huntsville, AL) against a C-terminal 14 amino acid oligopeptide fragment of IBAT and purified by immuno-affinity chromatography as described [ 17 ] . The ileal tissue segments were snap-frozen in -70°C cold isopentane and then stored in -70°C until the tissues were processed.
This may result in an altered programming of ileal stem cells and transit cells that give rise to absorptive enterocytes over-expressing IBAT protein.
In addition, IBAT may be yet another apical membrane transport protein that is regulated by CFTR.