Example sentences for: ibat

How can you use “ibat” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Increased bile acid transport in cftr (-/-) mice is associated with an increase in the abundance of IBAT protein in the brush border membrane.

  • Polyclonal rabbit antibodies were obtained from a commercial source (Research Genetics, Huntsville, AL) against a C-terminal 14 amino acid oligopeptide fragment of IBAT and purified by immuno-affinity chromatography as described [ 17 ] . The ileal tissue segments were snap-frozen in -70°C cold isopentane and then stored in -70°C until the tissues were processed.

  • In contrast, cftr (-/-) mice may experience bile acid malabsorption even though their ileal mucosal cells express four-fold more IBAT transporters than normal cells.

  • This increase in IBAT function was paralleled by increases in IBAT protein concentrations.

  • CFTR regulation of ENaC has been described in the colon in humans [ 37 ] and in cftr knockout mice [ 37 ] . Co-localization of CFTR and ENaC suggests that direct protein-protein interactions allow CFTR to closely regulate the activity of this channel [ 39 40 ] . Our results suggest that knockout of CFTR leads to an analogous increase in expression and function of IBAT.


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