Example sentences for: hypophosphorylated

How can you use “hypophosphorylated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To separate the specific role of hypophosphorylated RARα from the pleiotropic effects of the ligand, we expressed a non-phosphorylatable S77A mutant protein in human cancer cells.

  • We examined the role of hypophosphorylated RARα by mutating the cdk7 phosphorylation site in the receptor amino terminus (S77A).

  • pRB phosphorylation varies as a function of cell cycle phase; during G 1 the hypophosphorylated form predominates, while the hyperphosphorylated form accumulates during S, G 2 and M phase [ 14 15 16 ] . It is this hypophosphorylated form of pRB present during early and mid G 1 which functions to modify gene expression.

  • Upstream of AP-1 transcription factors, RA has been shown to inhibit epidermal growth factor receptor (EGFR) expression [ 14 ] . To determine if hypophosphorylated RARα could inhibit EGFR expression, we examined expression of the growth factor receptor by western blot in control and S77A mutant cells.

  • These data suggest that in the unliganded state, hypophosphorylated RARα can mimic the effects of RA on EGFR expression, ERK1 activity, and AP-1 protein levels.


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