Words similar to hypophosphorylated
Example sentences for: hypophosphorylated
How can you use “hypophosphorylated” in a sentence? Here are some example sentences to help you improve your vocabulary:
To separate the specific role of hypophosphorylated RARα from the pleiotropic effects of the ligand, we expressed a non-phosphorylatable S77A mutant protein in human cancer cells.
We examined the role of hypophosphorylated RARα by mutating the cdk7 phosphorylation site in the receptor amino terminus (S77A).
pRB phosphorylation varies as a function of cell cycle phase; during G 1 the hypophosphorylated form predominates, while the hyperphosphorylated form accumulates during S, G 2 and M phase [ 14 15 16 ] . It is this hypophosphorylated form of pRB present during early and mid G 1 which functions to modify gene expression.
Upstream of AP-1 transcription factors, RA has been shown to inhibit epidermal growth factor receptor (EGFR) expression [ 14 ] . To determine if hypophosphorylated RARα could inhibit EGFR expression, we examined expression of the growth factor receptor by western blot in control and S77A mutant cells.
These data suggest that in the unliganded state, hypophosphorylated RARα can mimic the effects of RA on EGFR expression, ERK1 activity, and AP-1 protein levels.
Loading...