Example sentences for: hypophosphorylated

How can you use “hypophosphorylated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These results indicate that decreased AP-1 protein expression correlates with AP-1 transcriptional inhibition by hypophosphorylated RARα.

  • Upstream of AP-1 transcription factors, RA has been shown to inhibit epidermal growth factor receptor (EGFR) expression [ 14 ] . To determine if hypophosphorylated RARα could inhibit EGFR expression, we examined expression of the growth factor receptor by western blot in control and S77A mutant cells.

  • This results in inhibition of CDK2 activity, accumulation of hypophosphorylated RB1, inactivation of E2F1 [ 45 ] , and cell cycle arrest.

  • Under conditions favoring proliferation, the phosphorylation of pRB via cyclin-dependent kinases (CDKs) in mid-to-late G 1 phase results in liberation of E2F and other pRB-bound transcription factors, which then activate the transcription of S-phase genes [ 19 ] . In late M phase, pRB returns to its growth suppressive, hypophosphorylated form due to the action of a pRB-directed protein phosphatase belonging to the type 1 class of serine/threonine protein phosphatases [ 11 20 21 ] .

  • Therefore while ligand bound RARα has been shown to activate a large number of RA target genes, the hypophosphorylated form of the receptor created in some cells following retinoid treatment may be important in transcriptional repression.


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