Words similar to hyperplasia
Example sentences for: hyperplasia
How can you use “hyperplasia” in a sentence? Here are some example sentences to help you improve your vocabulary:
The long-term treatment of patients with either CsA or TAC results in side effects such as nephrotoxicity, hypertension, and gingival hyperplasia [ 1 2 ] . Sirolimus (SRL) a new immunosuppressive agent is structurally similar to TAC binds to same binding protein FKBP, but its mechanism of action is different [ 3 ] . Both clinical and experimental studies demonstrated that SRL when used either with CsA or alone is associated with side effects such as hyperlipidemia, thrombocytopenia and nephrotoxicity [ 4 5 6 7 ] . Since SRL and TAC have affinity for the same binding site, it was thought to be ineffective when used together.
TTP also regulates the stability of GM-CSF (granulocyte/macrophage-colony-stimulating factor) mRNA through the ARE, and therefore TTP deficiency is associated with increased production of GM-CSF and with myeloid hyperplasia.
In order to determine if cyclin D 1 plays a role in this hyperplasia, kidneys from three proteinuric 40-day old transgenic siblings and three non-transgenic littermates were stained by immunohistochemistry with antibody to phospho-pRb (Ser780), a site of cyclin D 1 /CDK-4/6 phosphorylation not targeted by cyclin E/CDK-2 complexes that disrupts pRb/E2F binding for G 1 → S progression [ 24 ] . Figure 1depicts the intense, heterogeneous nuclear staining of glomerular podocytes and tubular epithelium from hyperplastic nephrons in the diseased transgenics versus the absent staining of nephrons in the non-transgenics consistent with the very low mitotic index in normal kidneys of adult animals [ 26 ] . This suggests that cyclin D 1 is promoting cell-cycle progression during the proliferation of epithelium in diseased kidneys.
Female mice harboring the Wnt-1 transgene develop extensive mammary hyperplasia early in life, and 50% of them develop mammary ductal carcinomas by 6 months of age [ 27].
While prostatic epithelium is resistant to neoplastic transformation, it is not resistant to the development of hyperplasia.
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