Words similar to hyperphosphorylation

Example sentences for: hyperphosphorylation

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A variety of autoantigens are cleaved into signature fragments during apoptosis and necrosis [ 20 ] . Other cell death post-translational modifications in autoantigens include hyperphosphorylation, (de)ubiquitination, methylation, citrullination, and transglutaminase crosslinking [ 21 22 ] .
In previous work, when this method was applied to MHCK-A-expressing cell lines the elevated expression of MHCK-A resulted in myosin II hyperphosphorylation and myosin II filament disassembly, and corresponding loss of ability of cells to grow in suspension [ 24 ] . We observed the same effect in the current studies in attempting to force high expression of FLAG-MHCK-C.
The pTX-MKC2 plasmid was therefore transfected into 3xALA myosin II cells, which are resistant to myosin filament hyperphosphorylation and disassembly due to elimination of phosphorylation target sites in the myosin tail [ 24 ] . The resultant 3xALA/pTX-MKC2 cells could be propagated in suspension culture even after selection for elevated expression in 40 μg/ml G418.
Furthermore, this hyperphosphorylation of Net1 in cdc14-1 cells was significantly reduced upon simultaneous inactivation of CDC5 (Figure 3, compare Lanes 3 and 4), suggesting that Cdc5 is at least partially responsible for the phosphorylation state of Net1 in late mitosis.