Example sentences for: hydrogen-bonding

How can you use “hydrogen-bonding” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • His114 corresponds to His98 of Fhit, which was localized in low barrier hydrogen-bonding distance to the α-β bridging oxygen of a bound ApppA analog in co-crystal structure with Fhit His96Asn [ 35].

  • However, the selected substitutions cannot always be conveniently rationalized: the R3-17 mutant differs from the wild-type T7 RNA polymerase at all the three amino acid positions (N748A; R756M; Q758S), replacing some amino acids with hydrophobic residues that do not likely form specific hydrogen-bonding interactions.

  • For example, residue N748 recognizes G-11 in the non-template strand via both direct and indirect hydrogen bonds; the N748D substitution has previously been hypothesized to form an alternate hydrogen-bonding network with the G-11C substitution [ 2 ] . Similarly, in the wild-type polymerase, residue Q758 makes a direct hydrogen bond to the adenosine at position -8 in the template strand.

  • The two amino-acid side chains differ in shape, hydrogen-bonding capability and degree of positive charge (arginine always being positively charged at physiological pH, histidine only having a positive charge about half the time).

  • A number of sequence-based features are also available, including calculation of alignment position statistics for a variety of physical-chemical properties: molecular volume [ 50], average pKa [ 50], hydrogen-bonding potential, number of rotatable bonds and hydrophobicity [ 51].


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