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Example sentences for: hus
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Clinical data indicate that the peak incidence of HUS occurs around two years of age, but the disease clearly occurs in significant numbers of older children [ 1 ] . Population-based studies suggest that there is a decline in the incidence of HUS from a peak at age 1-2 years until a nadir at about age 11 years [ 1 2 ] . In addition, a case-control study of the Washington State outbreak of HUS revealed that the mean age of patients with HUS was 8 years, while the mean age of patients without HUS was 15 years [ 3 ] . These studies raise the possibility, therefore, that the appearance or disappearance of a factor or factors in adolescents and adults reduces susceptibility to end-organ injury in HUS.
Next, we tested if the four other checkpoint radΔ alleles ( hus1Δ, rad1Δ, rad9Δ and rad17Δ ) conferred TBZ sensitivity (Figure 3).
Confirmation of these observations is needed, however they do suggest that Gb3 levels, and in particular the pattern of renal Gb3 expression, may be a factor in the age-related incidence of renal injury in HUS.
The rad26-GFP allele was crossed into five checkpoint radΔ alleles ( hus1Δ , rad1Δ , rad9Δ , rad17Δ and rad3Δ ) and Rad26-GFP localization was assayed in Triton X-100 extracted cells.
Based on histologic evidence, glomerular endothelial cells have been invoked as being primarily involved in HUS renal injury [ 7 ] . In vitro studies have demonstrated that human glomerular endothelial cells (HGEN) bind Stx-1 and are modestly sensitive to the toxin's cytotoxic effect [ 8 ] . Recent work indicates that other renal cell types may be Stx targets in HUS: cultured human proximal tubule (HPT) [ 9 ] and human visceral glomerular epithelial (HGEC) [ 10 ] cells express abundant amounts of Gb3 and are highly sensitive to the cytotoxic effect of Stx-1.
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