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Example sentences for: hus
How can you use “hus” in a sentence? Here are some example sentences to help you improve your vocabulary:
The rad26-GFP allele was crossed into five checkpoint radΔ alleles ( hus1Δ , rad1Δ , rad9Δ , rad17Δ and rad3Δ ) and Rad26-GFP localization was assayed in Triton X-100 extracted cells.
The reasons why HUS primarily affects children are unknown.
In fission yeast, the checkpoint rad +genes ( hus1 +, rad1 +, rad3 +, rad9 +, rad17 +and rad26 +) and chk1 +manage the sensing and transducing operations of the DNA damage checkpoint [ 1 16 ] . Current data suggest that the Rad26/Rad3-kinase complex initially senses DNA damage by an unknown mechanism [ 17 ] . This response leads to an increase in the kinase activity of the complex [ 18 ] , which phosphorylates and activates the transducing protein kinase, Chk1 [ 19 ] . Finally, Chk1 delays mitotic entry by targeting Cdc25 and Wee1, regulators of cyclin-dependent kinase activity [ 20 21 22 ] .
Clinical data indicate that the peak incidence of HUS occurs around two years of age, but the disease clearly occurs in significant numbers of older children [ 1 ] . Population-based studies suggest that there is a decline in the incidence of HUS from a peak at age 1-2 years until a nadir at about age 11 years [ 1 2 ] . In addition, a case-control study of the Washington State outbreak of HUS revealed that the mean age of patients with HUS was 8 years, while the mean age of patients without HUS was 15 years [ 3 ] . These studies raise the possibility, therefore, that the appearance or disappearance of a factor or factors in adolescents and adults reduces susceptibility to end-organ injury in HUS.
As stated earlier, there is no precedent in the literature for examination of the effect of sex steroids on Stx responsiveness, however, the coincidental fall in clinically apparent HUS in adolescents and adults [ 1 ] raises the possibility that hormonal changes associated with puberty induce a relatively Stx-resistant state in the kidney.
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