Words similar to hus
Example sentences for: hus
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Indeed, it is conceivable that not all of the factors involved in HUS occurrence in young children are identical to those involved in the diminished HUS incidence in adolescents and adults.
In particular, rad1Δ and rad9Δ are also sensitive to TBZ, while rad17Δ and hus1Δ are not (Figure 3).
For instance, they are dispensable for DNA damage-dependent activation of the Rad26/Rad3-kinase complex [ 18 ] , but are required for the Rad3-dependent phosphorylation of Chk1 [ 23 ] . Structural predictions of Hus1, Rad1 and Rad9 have led to the proposal that all three fold similarly to the subunits of Proliferating Cell Nuclear Antigen (PCNA) [ 24 25 26 ] . Consistent with these predictions, PCNA exists as a homotrimer [ 27 ] while Hus1, Rad1 and Rad9 all interact and possibly form a heterotrimer [ 25 28 ] . In addition, Rad17 has sequence similarity and physical interactions with subunits of Replication Factor C (RFC) [ 29 30 ] . Based on the RFC-PCNA paradigm, the Rad17-RFC complex may load the PCNA-like Rad9-Rad1-Hus1 (9-1-1) complex onto genomic lesions discovered by the Rad26/Rad3 complex.
HUS is thought to be due, at least in large part, to Shiga toxin (Stx)-mediated cell toxicity [ 4 ] . Since the kidney is a primary target of Stx in patients with HUS, it has been hypothesized that the preferential renal injury occurring in children with HUS is related to heightened renal susceptibility to Stx in this age group.
Traditional animal models, such as mice, rats, rabbits or pigs do not develop typical renal disease when given either Stx or E. coli 0157:H7 [ 14 ] . Further, animal models that most closely reflect human HUS are only in the early stages of development [ 14 ] . Hence, the cell culture system remains the most reasonable means to assess an effect of sex steroids on renal cell Stx-1 responsiveness; such systems have clearly been demonstrated to be responsive to sex steroids (e.g.
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