Words similar to hspgs
Example sentences for: hspgs
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Therefore, III1-C and endostatin may inhibit angiogenesis through related mechanisms involving both integrins and HSPGs.
10, most of the 46 kDa and 70 kDa HSPGs bound to III1-C Sepharose but not to III 11-C Sepharose.
RASMC HSPGs were analyzed further by immunoblotting with the monoclonal antibody 3G10 which specifically recognizes desaturated uronates on the heparan sulfate stubs that remain associated with core proteins after heparitinase digestion [ 37 ] . Complete digestion of RASMC lysates with heparitinase reveals major bands at 46 kDa and 70 kDa, indicating that these are the sizes of the major HSPG core proteins (not shown).
These results are one of the first demonstrations that HSPGs can activate the ERK signaling pathway.
There are 4 members in the syndecan family (syndecan-1 through-4) [ 39 40 ] . Syndecan-1, -2 and -4 are known to bind to extracellular matrix proteins and syndecan-1 and -4 have been shown to support stress fiber formation in conjunction with integrins [ 41 42 43 44 45 ] . The HSPGs we have identified as III1-C receptors have core proteins that migrate at the approximate sizes of syndecan-1 (~69 kDa core protein) and syndecan-2 (~48 kDa core protein) [ 40 ] . It is therefore possible that our 46 kDa and 70 kDa HSPGs represent syndecan family members.